Mishan, Mohammad Amir and Choo, Yeun-Mun and Winkler, Jeffery and Hamann, Mark T. and Karan, Dev (2025) Manzamine A: A promising marine-derived cancer therapeutic for multi-targeted interactions with E2F8, SIX1, AR, GSK-3β, and V-ATPase - A systematic review. European Journal of Pharmacology, 990. ISSN 0014-2999, DOI https://doi.org/10.1016/j.ejphar.2025.177295.
Full text not available from this repository.Abstract
Manzamine A, a natural compound derived from various sponge genera, features a beta-carboline structure and exhibits a range of biological activities, including anti-inflammatory and antimalarial effects. Its potential as an anticancer agent has been explored in several tumor models, both in vitro and in vivo, showing effects through mechanisms such as cytotoxicity, regulation of the cell cycle, inhibition of cell migration, epithelial-tomesenchymal transition (EMT), autophagy, and apoptosis through multi-target interactions of E2F transcriptional factors, ribosomal S6 kinases, androgen receptor (AR), SIX1, GSK-3 beta, v-ATPase, and p53/p21/p27 cascades. This systematic review evaluates existing literature on the potential application of this marine alkaloid as a novel cancer therapy, highlighting its promising ability to inhibit cancer cell growth while causing minimal side effects.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Manzamine A; SIX1; AR; GSK-3 beta; V-ATPases; Cell cycle regulation; Cancer therapy |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 02 Oct 2025 07:03 |
| Last Modified: | 02 Oct 2025 07:03 |
| URI: | http://eprints.um.edu.my/id/eprint/47967 |
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