Gafforov, Yusufjon and Bekic, Sofija and Yarasheva, Manzura and Miskovic, Jovana and Zivanovic, Nemanja and Chen, Jia Jia and Petri, Edward and Abdullaev, Bekhzod and Rapior, Sylvie and Lim, Young Won and Abdullaev, Ikram and Abbasi, Arshad Mehmood and Ghosh, Soumya and Wan-Mohtar, Wan Abd Al Qadr Imad and Raseta, Milena (2025) Bioactivity profiling of Sanghuangporus lonicerinus: antioxidant, hypoglycaemic, and anticancer potential via in-vitro and in-silico approaches. Journal of Enzyme Inhibition and Medicinal Chemistry, 40 (1). ISSN 1475-6366, DOI https://doi.org/10.1080/14756366.2025.2461185.
Full text not available from this repository.Abstract
This study investigates the mycochemical profile and biological activities of hydroethanolic (EtOH), chloroform (CHCl3), and hot water (H2O) extracts of Sanghuangporus lonicerinus from Uzbekistan. Antioxidant capacity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2 `-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), NO, and FRAP assays, and in vitro hypoglycaemic effects were evaluated through alpha-amylase and alpha-glucosidase inhibition. Antiproliferative potential was explored by analysing the binding affinities of EtOH and H2O extracts to estrogen receptor alpha (ER alpha), ER beta, androgen receptor (AR), and glucocorticoid receptor (GR), with molecular docking providing structural insights. LC-MS/MS analysis revealed solvent-dependent phenolic profiles, with the EtOH extract containing the highest total phenolic content (143.15 +/- 6.70 mg GAE/g d.w.) and the best antioxidant capacity. The EtOH extract showed significant hypoglycaemic effects, with 85.29 +/- 5.58% inhibition of alpha-glucosidase and 41.21 +/- 0.79% inhibition of alpha-amylase. Moderate ER beta binding suggests potential for estrogen-mediated cancer therapy, while strong AKR1C3 inhibition by the EtOH extract supports its therapeutic potential.
| Item Type: | Article |
|---|---|
| Funders: | Agency for Innovative Development under the Ministry of Higher Education, Science, and Innovation of the Republic of Uzbekistan [Grant No: AL-8724052922-R3], Ministry of Science, Technological Development, and Innovation of the Republic of Serbia [Grant No: 451-03-66/2024-03/200125], CAS PIFI [Grant No: 2022VBA0021], Science Fund of the Jiangsu Vocational College of Agriculture and Forestry [Grant No: 2024kj07; 2023kj16] |
| Uncontrolled Keywords: | Anticancer; Diabetes; Molecular docking; Phylogeny; Polyphenolics |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 05 Oct 2025 14:11 |
| Last Modified: | 05 Oct 2025 14:11 |
| URI: | http://eprints.um.edu.my/id/eprint/47821 |
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