Lui, Juliana N. M. and Lau, Eric S. H. and Li, Abby Q. Y. and Zhang, Yuzheng and Lim, Lee-Ling and Chun-KwunO, - and Wong, Kelly T. C. and Yang, Aimin and Wu, Hongjiang and Ma, Ronald C. W. and Kong, Alice P. S. and Ozaki, Risa and Luk, Andrea O. Y. and Chow, Elaine Y. K. and Chan, Juliana C. N. (2025) Temporal incremental healthcare costs associated with complications in Hong Kong Chinese patients with type 2 diabetes: A prospective study in Joint Asia diabetes evaluation (JADE) Register (2007-2019). Diabetes Research and Clinical Practice, 219. p. 111961. ISSN 0168-8227, DOI https://doi.org/10.1016/j.diabres.2024.111961.
Full text not available from this repository.Abstract
Objective: We examined incremental healthcare costs (inpatient and outpatient) related to complications in Chinese patients with type 2 diabetes (T2D) during the year of occurrence and post-event years, utilizing the Joint Asia Diabetes Evaluation (JADE) Register cohort of Hong Kong Chinese patients with T2D between 2007 and 2019. Research Design and Methods: 19,440 patients with T2D underwent structured evaluation utilizing the JADE platform with clinical outcomes data retrieved from territory-wide electronic medical records including inpatient, outpatient and emergency care. Two-part model was adopted to account for skewed healthcare costs distribution. Incremental healthcare costs associated with nine non-fatal diabetes complications and all-cause death were estimated, adjusted for demographic, clinical, lifestyle factors and comorbidities. Results: In this prospective cohort mean f SD age:59.9 f 11.9 years, 56.6 % men, duration of diabetes:7.3 f 7.5 years, HbA1C:7.5 f 1.6 %] observed for 7 (interquartile range:4-9) years (142,132 patient-years), the mean annual healthcare costs, mainly due to inpatient cost, were USD$2,990 f 9,960. Lower extremity amputation (LEA) (USD$31,302; 95 %CI: 25,706-37,004), hemorrhagic stroke (USD$21,164; 17,680-24,626), ischemic stroke (USD$17,976; $15,937-20,352) and end-stage disease (ESRD) (USD$14,774; 13,405-16,250) in the year of event incurred the highest cost. Residual healthcare costs in the post-event years were highest for ESRD, LEA, haemorrhagic stroke and incident cancer. Conclusion: These comprehensive temporal healthcare cost estimates for diabetes-related complications allows the performance of long-term, patient-level, cost-effectiveness analyses on T2D prevention and treatment strategies relevant to an Asian and possibly global contexts. These may inform decision-makers on resource allocation aimed at reducing the burden of T2D and chronic diseases.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Diabetes complications; Type 2 diabetes; Temporal incremental healthcare costs |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Universiti Malaya |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Mar 2025 05:12 |
| Last Modified: | 03 Mar 2025 05:12 |
| URI: | http://eprints.um.edu.my/id/eprint/47789 |
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