Wardana, Andika Pramudya and Kristanti, Alfinda Novi and Aminah, Nanik Siti and Fahmi, Mochamad Zakki and Raoov, Muggundha and Indriani, - (2024) Breast Cancer Chemoprevention from Nano Zingiber officinale Roscoe. International Journal of Nanomedicine, 19. pp. 11039-11053. ISSN 1178-2013, DOI https://doi.org/10.2147/IJN.S474611.
Full text not available from this repository.Abstract
Background: After cardiovascular disease, cancer is one of the leading causes of death due to uncontrolled cell growth. Breast cancer is among the most prevalent types of cancer. Zingiber officinale Roscoe. rich in phenolic compounds, which can stimulate and function as endogenous antioxidants. Purpose: Investigation of the in vivo chemopreventive has the potential of nano Z. officinale Roscoe (Zo-NPs) in breast cancer. Study Design: Using female Mus musculus Balb/c induced with benzoalpha]pyrene, the chemopreventive action of Z. officinale Roscoe. nanoencapsulated using kappa-carrageenan was assessed. Results: Z. officinale Roscoe Extract. contains 58 compounds, with the main component being 6]-gingerol with 6]-gingerol content being 697.65 +/- 8.52 mg/g extract. Nanoencapsulation of Z. officinale Roscoe. has been successfully prepared with a particle size of 483.30 +/- 11.23 nm. Zo-NPs are generally resistant to pH, temperature, and salt content variations. Compared to group C1, which underwent ductular dilatation, the administration of Zo-NPs (group T2) to female Mus musculus Balb/c, induced by benzoalpha]pyrene, revealed no histological alterations in breast tissue. Moreover, administering Zo-NPs can raise blood serum levels of CAT, GSH, and SOD. In addition, it showed a greater ability to lower TNF-alpha levels than the T1 group, which received Z. officinale Roscoe extract. (Zo).
| Item Type: | Article |
|---|---|
| Funders: | Universitas Airlangga "Penelitian Unggulan Airlangga 2023 (PUA)" (293/UNS.15/FT/2023) |
| Uncontrolled Keywords: | breast cancer; chemopreventive; nanoencapsulation; red ginger; Zingiber officinale Roscoe |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Jan 2025 01:11 |
| Last Modified: | 17 Jan 2025 01:11 |
| URI: | http://eprints.um.edu.my/id/eprint/47657 |
Actions (login required)
 |
View Item |
