Wee, Ai Sze and Thew, Hin Yee and Liew, Sook Yee and Tan, Wen Nee and Khaw, Kooi Yeong (2024) Anti-cholinesterase profile of Murraya koenigii (L.) Spreng essential oil and its chemical constituents. Journal of Essential Oil Bearing Plants, 27 (5). pp. 1449-1459. ISSN 0972-060X, DOI https://doi.org/10.1080/0972060X.2024.2398676.
Full text not available from this repository.Abstract
Traditionally, Murraya koenigii (L.) Spreng has been used as an ingredient in medicinal formulations. Several studies have reported on the potential of M. koenigii leaves to enhance learning and memory functions in animal models. This study aimed to identify the chemical constituents and evaluate the anti-cholinesterase activity of the essential oil extracted from M. koenigii leaves. The essential oil extracted via hydrodistillation was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 41 constituents were identified, with beta-phellandrene (35.42%), beta-caryophyllene (16.79%) and alpha-pinene (17.75%) predominating in the essential oil. Using Ellman's colorimetric method, the M. koenigii essential oil demonstrated potent inhibitory activity against acetylcholinesterase (AChE), with an IC50 value of 36.89 mu g/mL. Interestingly, a mixture of the three major constituents (beta-phellandrene, beta-caryophyllene, and alpha-pinene) was more effective than the individual constituents (beta-caryophyllene and alpha-pinene). In conclusion, the study on the neuroprotective effects of M. koenigii essential oil has yielded promising results.
| Item Type: | Article |
|---|---|
| Funders: | Royal Soceity of Chemistry Research fund (R21-3147089079), School of Pharmacy, Monash University Malaysia (SOP/SRG-ECR(R2)/06/2022) |
| Uncontrolled Keywords: | Anti-acetylcholinesterase; Murraya koenigii; Essential oil; Hydrodistillation; Mono-terpenes; Sesquiterpenes |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Centre for Foundation Studies in Science > Chemistry Division Centre for Natural Products Research and Drug Discovery (CENAR) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Feb 2025 03:05 |
| Last Modified: | 17 Feb 2025 03:05 |
| URI: | http://eprints.um.edu.my/id/eprint/47420 |
Actions (login required)
 |
View Item |
