Brassington, Layla and Arner, Audrey M. and Watowich, Marina M. and Damstedt, Jane and Ng, Kee Seong and Lim, Yvonne A. L. and Venkataraman, Vivek V. and Wallace, Ian J. and Kraft, Thomas S. and Lea, Amanda J. (2024) Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease risk. Evolution, Medicine, and Public Health, 12 (1). pp. 214-226. ISSN 2050-6201, DOI https://doi.org/10.1093/emph/eoae014.
Full text not available from this repository.Abstract
Decades ago, Neel's Thrifty Genotype Hypothesis posited that human evolutionary history and environmental change interact to influence cardiometabolic health. We discuss the history, evidence, and modern day interpretation of this idea. We also provide possible study designs for empirical tests, focusing on working with subsistence-level groups undergoing lifestyle transitions.
| Item Type: | Article |
|---|---|
| Funders: | Orang Asli Health and Lifeways Project, Center for Orang Asli Concerns, Malaysian Red Crescent Society, Federation of Private Medical Practitioners' Associations of Malaysia, Hospital Orang Asli Gombak, Universiti Malaya |
| Uncontrolled Keywords: | Thrifty Genotype Hypothesis; Evolutionary Mismatch Hypothesis; genotype x environment interactions; Orang Asli |
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Faculty of Medicine > Medicine Department Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Feb 2025 01:46 |
| Last Modified: | 18 Feb 2025 01:46 |
| URI: | http://eprints.um.edu.my/id/eprint/47384 |
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