Zin, Ruziana Mona Wan Mohd and Jalaludin, Muhammad Yazid and Md Zain, Fuziah and Hong, Janet Yeow Hua and Kamil, Nur Zati Iwani Ahmad and Mokhtar, Abdul Halim and Wan Mohamud, Wan Nazaimoon (2024) Lifestyle intervention improves cardiometabolic profiles among children with metabolically healthy and metabolically unhealthy obesity. Diabetology & Metabolic Syndrome, 16 (1). p. 268. ISSN 1758-5996, DOI https://doi.org/10.1186/s13098-024-01493-8.
Full text not available from this repository.Abstract
Background In recent years, there has been a surge of interest in the metabolic phenotype among children with obesity characterized by the absence of associated cardiometabolic risk factors (CRFs), known as metabolically healthy obesity (MHO), as opposed to those with metabolically unhealthy obesity (MUO). This study investigated the effect of lifestyle intervention on CRFs among children with MHO and MUO. Methods A total of 102 school-aged children with obesity (54 girls and 48 boys) aged 8-16 years completed a 16-week school-based lifestyle modification intervention program, MyBFF@school Phase I. The intervention consisted of physical activity, healthy eating promotion, and psychological empowerment. MHO and MUO statuses were defined based on the 2018 consensus-based criteria. Fasting venous blood collection, body composition measurement, clinical assessment and physical fitness testing were conducted at baseline and at the end of week 16. Results After the intervention, the CRFs of the children with MUO improved with significant decreases in systolic (p < 0.001) and diastolic (p = 0.01) blood pressure and a significant increase in high-density lipoprotein cholesterol (HDL-C) (p = 0.005), while the CRFs of the children with MHO had a significant decrease in uric acid (p = 0.04). Additionally, 51.6% of the children with MHO transitioned to the MUO, while 26.8% of the children with MUO crossed over to the MHO at the end of the intervention. Furthermore, the odds of having high systolic blood pressure among children with MUO were 59% lower at week-16 than at baseline (OR = 0.41 (95% CI = 0.18, 0.92), p = 0.03). Conclusions Our findings demonstrated that CRFs improved more prominently among children with MUO following the intervention. More importantly, our findings indicate that MHO in children is transient, hence, strategies to protect children against MUO are warranted. Conclusions Our findings demonstrated that CRFs improved more prominently among children with MUO following the intervention. More importantly, our findings indicate that MHO in children is transient, hence, strategies to protect children against MUO are warranted.
| Item Type: | Article |
|---|---|
| Funders: | Kementerian Kesihatan Malaysia, Ministry of Education |
| Uncontrolled Keywords: | School children; Paediatric obesity; Cardiometabolic risk factors; Lifestyle intervention; School-based intervention; Metabolic phenotype |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Paediatrics Department Faculty of Medicine > Sport Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 24 Feb 2025 01:16 |
| Last Modified: | 24 Feb 2025 01:16 |
| URI: | http://eprints.um.edu.my/id/eprint/47321 |
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