Zhao, Ze-Yu and Zang, Yi and Li, Jia and Choo, Yeun-Mun and Xiong, Juan and Hu, Jin-Feng (2024) Fortunefuroic Acid J from Keteleeria Hainanensis and its Dual Inhibitory Effects on ATP-Citrate Lyase and Acetyl-CoA Carboxylase. Chemistry & Biodiversity, 21 (12). e202401520. ISSN 1612-1872, DOI https://doi.org/10.1002/cbdv.202401520.
Full text not available from this repository.Abstract
A previously undescribed triterpenoid (fortunefuroic acid J, 1) was isolated from the endangered conifer Keteleeria hainanensis, along with 20 other known terpenoids. Compound 1 is characterized by an unusual 3,4-seco-9 beta H-lanost-3-oic acid motif, featuring a rare furoic acid moiety in its lateral chain. The structure elucidation of this compound was achieved through a combination of spectroscopic and computational methods. The C-15 epimers of 15-methoxypinusolidic acid (15R-8 and 15S-9) were successfully separated and identified for the first time. Compound 1 demonstrated dual inhibitory effects against ATP-citrate lyase (ACL, IC50: 0.92 mu M) and acetyl-CoA carboxylase 1 (ACC1, IC50: 10.76 mu M). Compounds 2 and 11 exclusively inhibited ACL, exhibiting IC50 values of 2.64 and 6.35 mu M, respectively. Compound 1 is classified among the fortunefuroic acid-type compounds, previously isolated from K. fortunei, distinguished by the presence of a rare furoic acid moiety in their lateral chain. The chemotaxonomic significance of the 9 beta H-lanost-26-oic acids in Keteleeria was briefly discussed. These findings highlight the importance of conserving plant species diversity, thereby enhancing the exploration of structurally diverse compounds and potential avenues for developing new therapeutics targeting ACL/ACC1-associated diseases.
| Item Type: | Article |
|---|---|
| Funders: | National Natural Science Foundation of China (NSFC) (21937002) ; (81773599), Natural Science Foundation of Zhejiang Province (LY23H300001) |
| Uncontrolled Keywords: | Keteleeria hainanensis; Pinaceae; Fortunefuroic acid; ATP-citrate lyase; Acetyl-CoA carboxylase 1; Natural products; Terpenoids |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 24 Feb 2025 02:49 |
| Last Modified: | 24 Feb 2025 02:49 |
| URI: | http://eprints.um.edu.my/id/eprint/47275 |
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