Tay, Matthew Zirui and Tang, Weiyi and Lee, Wenn-Chyau and Ong, Alice Soh Meoy and Novera, Wisna and Malleret, Benoit and Carissimo, Guillaume and Chacko, Ann-Marie and El-Sahili, Abbas and Lescar, Julien and Fan, Yiping and McGready, Rose M. and Chu, Cindy S. and Chan, Jerry Kok Yen and Ng, Lisa F. P. and Russell, Bruce and Nosten, Francois and Renia, Laurent (2024) Functional and Immunologic Mapping of Domains of the Reticulocyte-Binding Protein Plasmodium vivax PvRBP2a. Journal of Infectious Diseases, 230 (3). e737-e742. ISSN 0022-1899, DOI https://doi.org/10.1093/infdis/jiae111.
Full text not available from this repository.Abstract
We previously described a novel Plasmodium vivax invasion mechanism into human reticulocytes via the PvRBP2a-CD98 receptor-ligand pair. Using linear epitope mapping, we assessed the PvRBP2a epitopes involved in CD98 binding and recognized by antibodies from patients who were infected. We identified 2 epitope clusters mediating PvRBP2a-CD98 interaction. Cluster B (PvRBP2a431-448, TAALKEKGKLLANLYNKL) was the target of antibody responses in humans infected by P vivax. Peptides from each cluster were able to prevent live parasite invasion of human reticulocytes. These results provide new insights for development of a malaria blood-stage vaccine against P vivax. Here, we identify 2 clusters of epitopes mediating the functional interaction between the Plasmodium vivax invasion ligand PvRBP2a and its host receptor CD98. Our data reveal important epitopes for development of a P vivax blood-stage vaccine.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | CD98; invasion; Plasmodium vivax; PVRBP2a; reticulocytes |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Jan 2025 08:55 |
| Last Modified: | 07 Jan 2025 08:55 |
| URI: | http://eprints.um.edu.my/id/eprint/47028 |
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