Secondary metabolites in topical infectious diseases and nanomedicine applications

Sahoo, Ankit and Dwivedi, Khusbu and Almalki, Waleed H. and Mandal, Ashok Kumar and Alhamyani, Abdurrahman and Afzal, Obaid and Alfawaz Altamimi, Abdulmalik Saleh and Alruwaili, Nabil K. and Yadav, Pradip Kumar and Barkat, Md Abul and Singh, Tanuja and Rahman, Mahfoozur (2024) Secondary metabolites in topical infectious diseases and nanomedicine applications. Nanomedicine, 19 (13). pp. 1191-1215. ISSN 1743-5889, DOI https://doi.org/10.2217/nnm-2024-0017.

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Official URL: https://doi.org/10.2217/nnm-2024-0017

Abstract

Topical infection affects nearly one-third of the world's population; it may result from poor sanitation, hygienic conditions and crowded living and working conditions that accelerate the spread of topical infectious diseases. The problems associated with the anti-infective agents are drug resistance and long-term therapy. Secondary metabolites are obtained from plants, microorganisms and animals, but they are metabolized inside the human body. The integration of nanotechnology into secondary metabolites is gaining attention due to their interaction at the subatomic and skin-tissue levels. Hydrogel, liposomes, lipidic nanoparticles, polymeric nanoparticles and metallic nanoparticles are the most suitable carriers for secondary metabolite delivery. Therefore, the present review article extensively discusses the topical applications of nanomedicines for the effective delivery of secondary metabolites.

Item Type: Article
Funders: Deanship for Research & Innovation, Ministry of Education, Saudi Arabia (IFP22UQU4310387DSR158)
Uncontrolled Keywords: bacteria; fungi; nanomedicine; nanotoxicology; secondary metabolites; skin; topical infection; virus
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Jan 2025 00:25
Last Modified: 13 Jan 2025 00:25
URI: http://eprints.um.edu.my/id/eprint/46971

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