Taufik, Sharifah Azira and Ramli, Norlina and Tan, Ai Huey and Lim, Shen -Yang and Ghani, Mohd Taufiq Abdul and Shahrizaila, Nortina (2024) Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease. Journal of Clinical Neurology, 20 (3). pp. 285-292. ISSN 1738-6586, DOI https://doi.org/10.3988/jcn.2023.0353.
Full text not available from this repository.Abstract
Background and Purpose There is increasing evidence that the anterior visual pathways are involved in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). This study investigated longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with ALS and PD with the aim of better understanding their roles as biomarkers of disease progression. Methods This study recruited 21 ALS patients, 19 age-matched PD patients, and 21 agematched healthy controls. Patient demographics and clinical scores relating to the respective diseases were documented. The RNFL thickness was measured using optical coherence tomography at baseline and after 6 months. Results At baseline, the RNFL in the superior quadrant was significantly thinner in the patients with ALS than in healthy controls (109.90 +/- 22.41 um vs. 127.81 +/- 17.05 um mean +/- standard deviation], p=0.008). The RNFL thickness did not differ significantly between the ALS and PD patients or between the PD patients and healthy controls. At 6 months, there was further significant RNFL thinning in patients with ALS, for both the overall thickness (baseline: median=94.5 um, range=83.0-106.0 um; follow-up: median=93.5 um, range=82.5-104.5 um, p=0.043) and the thickness in the inferior quadrant (median=126 um, range=109.5-142.5 um; and median=117.5 um, range=98.5-136.5 um; respectively, p=0.032). However, these changes were not correlated with the ALS functional scores. In contrast, the patients with PD did not demonstrate a significant change in RNFL thickness between the two time points. Conclusions The RNFL thickness is a promising biomarker of disease progression in patients with ALS but not in those with PD, which has a slower disease progression.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | retinal nerve fiber layer; amyotrophic lateral sclerosis; Parkinson disease; optical coherence tomography |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Department of Ophthalmology Faculty of Medicine > Social & Preventive Medicine Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Jan 2025 00:36 |
| Last Modified: | 13 Jan 2025 00:36 |
| URI: | http://eprints.um.edu.my/id/eprint/46965 |
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