Wong, Hoi Yee and Pui Li, Wong and Abdul Kahar, Maria Kahar Bador and Chong, Meng Li and Shenoi, Sheela and Rozanova, Julia and Syed Omar, Sharifah Faridah and Neelamegam, Malinee and Lee, Yew Kong and Rajasuriar, Reena (2024) Causes, risks and care circumstances associated with death in older adults diagnosed with HIV in a tertiary centre in Malaysia. International Journal of STD and AIDS, 35 (9). pp. 710-720. ISSN 0956-4624, DOI https://doi.org/10.1177/09564624241250378.
Full text not available from this repository.Abstract
Background: A substantial number of older adults succumb soon after HIV diagnosis despite ART. We explored the causes, risk factors and circumstances before death among older adults acquring HIV. Methods: We recruited individuals newly diagnosed at our centre from 2016-2020 and analysed data of those who died. Patients were stratified to older (>= 50 years) or younger (<50 years) based on their age at diagnosis and attributes were compared. The Cox proportional multivariable model was used to identify factors associated with all-cause mortality. Results: Among 75 deaths reported, the majority of deaths were AIDS-related and late presentation was common in both age groups. The majority of deaths occurred in the first 12 months after care presentation and over two-thirds in both groups disengaged from care prior to death. Older age remained an independent factor associated with death after adjusting for confounders including opportunistic infections, late presentation to care, ART initiation and chronic comorbidities at presentation. Conclusion: Most causes of death in our setting were AIDS-related and associated with late care presentation both in young and older individuals, although older age at diagnosis remained an independent risk factor. Our findings highlight the urgent need to encourage prompt ART initiation following diagnosis, especially in older adults.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Advanced HIV disease; AIDS-related; older adults; late presentation; mortality |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department Faculty of Medicine > Primary Care Medicine Department Centre of Excellence for Research in AIDS (CERiA) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Jan 2025 02:20 |
| Last Modified: | 13 Jan 2025 02:20 |
| URI: | http://eprints.um.edu.my/id/eprint/46946 |
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