Abouelazayem, Mohamed and Jain, Rajesh and Wilson, Michael S. J. and Martinino, Alessandro and Balasubaramaniam, Vignesh and Biffl, Walter and Coccolini, Federico and Riera, Manel and Wadhawan, Himanshu and Wazir, Ishaan and Abderaouf, Bettahar and Abramov, Daniil and Abu Jayyab, Mustafa A. and Al-Shami, Khayry and Alfarwan, Ahmad and Alhajami, Faris M. and Alkaseek, Akram and Alozairi, Ous and Ammar, Ahmed Siddique and Atar, Burak and Baatarjav, Gan-Erdene and Bains, Lovenish and Bakri, Ashraf and Bayramov, Nuru and Bhojwani, Rajesh and Brachini, Gioia and Calini, Giacomo and Campanelli, Michela and Cheng, Shi Yu and Choudhary, Charan Singh and Chowdhury, Sharfuddin and Colak, Elif and Das, Jayanta Kumar and Dawani, Surrendar and Donmez, Turgut and Elzayat, Ibrahim and Erdene, Sarnai and Faizi, Tashaba Qaiser and Frountzas, Maximos and Gafsi, Besma and Gentileschi, Paolo and Guler, Mert and Gupta, Gaurav and Harkati, Nour Elhouda and Harris, Matthew and Hasan, Doaa M. and Irowa, Omorodion Omoruyi and Jafferi, Salman and Jain, Sumita Agarwal and Han, Lai Jun and Kandiboyina, Satyanarayana Murthy and Karabulut, Mehmetu and Khamees, Almu'atasim and Khan, Shahzeb and Khan, Madiha Masood and Khaw, Cheng Jing and Kisielewski, Michal and Klib, Mohamad and Kosir, Jurij A. and Krawczyk, Wiktor Jan and Lisi, Giorgio and Makama, Jerry Godfrey and Maqbool, Baila and Marques, Claudia Neves and Meric, Serhat and Mietla, Mateusz Przemyslaw and Ads, Alaa Mohamed and Muhumuza, Joshua and Mulita, Francesk and Mustafayeva, Matanat and Omar, Mohammed A. and Omarov, Taryel and Pathak, Akshant Anil and Paul, Ratnadeep and Pavone, Giovanna and Podda, Mauro and Ram, Novinth Kumar Raja and Rauf, Fatima and Rauf, Sidra and Safy, Ahmed Mohamed and Sandag, Erdene and Sanli, Ahmet Necati and Siddiqui, Adeela Z. and Sotiropoulou, Maria and Talib, Vikash and Tatar, Cihad and Thota, Anuroop and Tokocin, Merve and Tolat, Aditya and Uchikov, Petar Angelov and Valenzuela, Jose I. and Venkatappa, Sunil Kumar and Verras, Georgios-Ioannis and Vlahovic, Ivan and Zreeg, Dafer Abdulhakim S. and Cardoso, Victor Roth and Gkoutos, Georgios V. and Singhal, Rishi and Mahawar, Kamal and Grp, GRACE Study Collaborative (2024) Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study. Surgical Endoscopy and Other Interventional Techniques, 38 (8). pp. 4402-4414. ISSN 0930-2794, DOI https://doi.org/10.1007/s00464-024-10881-0.
Full text not available from this repository.Abstract
Background There is little international data on morbidity and mortality of surgery for perforated peptic ulcer (PPU). This study aimed to understand the global 30-day morbidity and mortality of patients undergoing surgery for PPU and to identify variables associated with these. Method We performed an international study of adults (>= 18 years) who underwent surgery for PPU from 1st January 2022 to 30th June 2022. Patients who were treated conservatively or had an underlying gastric cancer were excluded. Patients were divided into subgroups according to age (<= 50 and >50 years) and time from onset of symptoms to hospital presentation (<= 24 and > 24 h). Univariate and Multivariate analyses were carried out to identify factors associated with higher 30-day morbidity and mortality. Results 1874 patients from 159 centres across 52 countries were included. 78.3% (n = 1467) of the patients were males and the median (IQR) age was 49 years (25). Thirty-day morbidity and mortality were 48.5% (n = 910) and 9.3% (n = 174) respectively. Median (IQR) hospital stay was 7 (5) days. Open surgery was performed in 80% (n = 1505) of the cohort. Age > 50 years (OR = 1.7, 95% CI 1.4- 2), (OR = 4.7, 95% CI 3.1- 7.6)], female gender (OR = 1.8, 95% CI 1.4-2.3), (OR = 1.9, 95% CI 1.3-2.9)], shock on admission (OR = 2.1, 95% CI 1.7-2.7), (OR = 4.8, 95% CI 3.2- 7.1)], and acute kidney injury (OR = 2.5, 95% CI 1.9-3.2), (OR = 3.9), 95% CI 2.7-5.6)] were associated with both 30-day morbidity and mortality. Delayed presentation was associated with 30-day morbidity OR = 1.3, 95% CI 1.1-1.6], but not mortality. Conclusions This study showed that surgery for PPU was associated with high 30-day morbidity and mortality rate. Age, female gender, and signs of shock at presentation were associated with both 30-day morbidity and mortality. GRAPHICS] .
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Global surgery; Perforated peptic ulcer; Gastrointestinal |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RD Surgery |
| Divisions: | Faculty of Medicine > Surgery Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Apr 2025 06:12 |
| Last Modified: | 09 Apr 2025 06:12 |
| URI: | http://eprints.um.edu.my/id/eprint/46714 |
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