Kunnath, Anil Philip and Suoodh, Mohamed Suodha and Chellappan, Dinesh Kumar and Chellian, Jestin and Palaniveloo, Kishneth (2024) Bacterial Persister Cells and Development of Antibiotic Resistance in Chronic Infections: An Update. British Journal of Biomedical Science, 81. p. 12958. ISSN 0967-4845, DOI https://doi.org/10.3389/bjbs.2024.12958.
Full text not available from this repository.Abstract
The global issue of antimicrobial resistance poses significant challenges to public health. The World Health Organization (WHO) has highlighted it as a major global health threat, causing an estimated 700,000 deaths worldwide. Understanding the multifaceted nature of antibiotic resistance is crucial for developing effective strategies. Several physiological and biochemical mechanisms are involved in the development of antibiotic resistance. Bacterial cells may escape the bactericidal actions of the drugs by entering a physiologically dormant state known as bacterial persistence. Recent findings in this field suggest that bacterial persistence can be one of the main sources of chronic infections. The antibiotic tolerance developed by the persister cells could tolerate high levels of antibiotics and may give rise to persister offspring. These persister offspring could be attributed to antibiotic resistance mechanisms, especially in chronic infections. This review attempts to shed light on persister-induced antibiotic resistance and the current therapeutic strategies.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | bacterial persister cells; biofilms; chronic infections; antibiotic resistance; antibiotic tolerance |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 10 Apr 2025 03:13 |
| Last Modified: | 10 Apr 2025 03:13 |
| URI: | http://eprints.um.edu.my/id/eprint/46694 |
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