Siti-Zubaidah, Mohd Zahari and Harafinova, Harman-Shah and Liba, Abdullahi Nuradeen and Nordin, Muhammad Luqman and Hambali, Kamarul Ariffin and Siti, Hawa Nordin (2024) Exploring bradykinin: A common mediator in the pathophysiology of sepsis and atherosclerotic cardiovascular disease. Vascular Pharmacology, 156. p. 107414. ISSN 1537-1891, DOI https://doi.org/10.1016/j.vph.2024.107414.
Full text not available from this repository.Abstract
Sepsis and atherosclerotic cardiovascular disease (ASCVD) are major health challenges involving complex processes like inflammation, renin-angiotensin system (RAS) dysregulation, and thrombosis. Despite distinct clinical symptoms, both conditions share mechanisms mediated by bradykinin. This review explores bradykinin's role in inflammation, RAS modulation, and thrombosis in sepsis and ASCVD. In sepsis, variable kininogen-bradykinin levels may correlate with disease severity and progression, though the effect of bradykinin receptor modulation on inflammation remains uncertain. RAS activation is present in both diseases, with sepsis showing variable or low levels of Ang II, ACE, and ACE2, while ASCVD consistently exhibits elevated levels. Bradykinin may act as a mediator for ACE2 and AT2 receptor effects in RAS regulation. It may influence clotting and fibrinolysis in sepsis-associated coagulopathy, but evidence for an antithrombotic effect in ASCVD is insufficient. Understanding bradykinin's role in these shared pathologies could guide therapeutic and monitoring strategies and inform future research.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Sultan Zainal Abidin (UniSZA/2021/DPU1.0/15 (R0319)) |
| Uncontrolled Keywords: | Bradykinin; Sepsis; Atherosclerosis; Inflammation; Angiotensin |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 10 Apr 2025 03:25 |
| Last Modified: | 10 Apr 2025 03:25 |
| URI: | http://eprints.um.edu.my/id/eprint/46688 |
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