Li Chan, Yun and Tang, Soo Nee and Osman, Che Puteh and Chee, Chin Fei and Tay, Sun Tee (2024) Exploring naphthoquinone and anthraquinone derivatives as antibiotic adjuvants against Staphylococcus aureus biofilms: Synergistic effects of menadione. Microbial Pathogenesis, 195. p. 106886. ISSN 0882-4010, DOI https://doi.org/10.1016/j.micpath.2024.106886.
Full text not available from this repository.Abstract
Given the ability of Staphylococcus aureus to form biofilms and produce persister cells, making infections difficult to treat with antibiotics alone, there is a pressing need for an effective antibiotic adjuvant to address this public health threat. In this study, a series of quinone derivatives were evaluated for their antimicrobial and antibiofilm activities against methicillin-susceptible and methicillin-resistant S. aureus reference strains. Following analyses using broth microdilution, growth curve analysis, checkerboard assay, time-kill experiments, and confocal laser scanning microscopy, menadione was identified as a hit compound. Menadione exhibited a notable antibacterial profile (minimum inhibitory concentration, MIC = 4-16 mu g/ml; minimum bactericidal concentration, MBC = 256 mu g/ml) against planktonic S. aureus and its biofilms (minimum biofilm inhibitory concentration, MBIC50 = 0.0625-0.25 mu g/ml). When combined with oxacillin, erythromycin, and vancomycin, menadione exhibited a synergistic or additive effect against planktonic cells and biofilms of two S. aureus reference strains and six clinical isolates, highlighting its potential as a suitable adjuvant for further development against S. aureus biofilm-associated infections.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (IIRG003-19FNW) ; (ST030-2022), Ministry of Education, Malaysia (FP070-2022) |
| Uncontrolled Keywords: | Antimicrobial agents; Antibiofilm activity; MRSA; Naphthoquinone; Antibiotic adjuvant |
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medical Microbiology Department Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Apr 2025 07:28 |
| Last Modified: | 14 Apr 2025 07:28 |
| URI: | http://eprints.um.edu.my/id/eprint/46582 |
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