Poh, Kim Yan and Bee, Ping Chong (2024) First report of Hb youngstown in capillary electrophoresis and overlapping Hb analysis findings with Hb rush. Hemoglobin, 48 (4). pp. 254-257. ISSN 0363-0269, DOI https://doi.org/10.1080/03630269.2024.2398236.
Full text not available from this repository.Abstract
Hb Youngstown HBB:c.305A > C] is a rare unstable hemoglobin caused by the substitution of glutamic acid with alanine at codon 101 of the Beta globin chain. It causes hemolytic anemia in the heterozygous state. This is a case of a six-year-old Chinese-Javanese girl with heterozygous Hb Youngstown and clinical features of chronic hemolysis and iron overload. Hb Youngstown appears at the S window near to 4.6 minutes on high-performance liquid chromatography (HPLC) and can form a hybrid tetramer on alkaline gel electrophoresis seen as two distinct bands cathodal to A and close to F. For the first time, Hb Youngstown is captured with capillary electrophoresis (CE) and shown to be eluted at zone 8. Clinical presentation and Hb analysis results of this heterozygous Hb Youngstown overlap with heterozygous Hb Rush. They can only be differentiated at molecular level by Beta globin gene sequencing or intact mass spectrometry.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Hb Youngstown; Hb Rush; Unstable hemoglobin; Hybrid tetramer |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 21 Oct 2025 01:28 |
| Last Modified: | 21 Oct 2025 01:28 |
| URI: | http://eprints.um.edu.my/id/eprint/46533 |
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