Alnajar, Maged and Saker, Zahraa and Haji, Fatma and Abdelsamed, Menna A. and Khaled, Zeinab and Abd-ElGawad, Mohamed (2024) Antipyretic effect of oral dipyrone (Metamizole) compared to oral ibuprofen in febrile children: A systematic review and meta-analysis. BMC Pediatrics, 24 (1). ISSN 1471-2431, DOI https://doi.org/10.1186/s12887-024-05095-1. (In Press)
Full text not available from this repository.Abstract
BackgroundDipyrone (Metamizole) is a potent pain reliever and fever reducer with muscle relaxant properties, most commonly used as an analgesic and antipyretic agent. Despite the fact that it has been banned in many high-income countries following confirmed studies of fatal agranulocytosis and adverse drug reactions, it is still widely used in various countries of the world. However, the antipyretic therapeutic indications of dipyrone in febrile children are currently unknown, and there is little information on the advantages and disadvantages of using dipyrone in febrile children. In febrile children, we expected that dipyrone's antipyretic effectiveness wouldn't be any more effective than ibuprofen. Therefore, the purpose of this research is to evaluate the effectiveness of oral dipyrone and oral ibuprofen as antipyretics in febrile children.MethodsSeveral databases, including PubMed, Scopus, Web of Science, and Cochrane Library, were searched thoroughly using a pre-established search strategy for potential research. The studies included in this analysis comprised randomized controlled trials that compared the antipyretic effects of oral ibuprofen and oral dipyrone in febrile children. Data analysis was carried out using RevMan 5.4 software.ResultsThree studies were selected among the 27 publications we discovered to be applicable, and they underwent qualitative and quantitative analysis. The pooled analysis revealed no discernible difference between oral dipyrone and oral ibuprofen in terms of their antipyretic effects (Mean difference (MD) = 0.06; 95% confidence interval (CI): -0.08, 0.20).ConclusionBoth oral dipyrone and ibuprofen are effective in reducing high-temperature levels in febrile children without any significant difference.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Antipyretic effect; Febrile Children; Oral dipyrone; Oral ibuprofen; Temperature |
| Subjects: | R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Oct 2025 00:58 |
| Last Modified: | 30 Oct 2025 00:58 |
| URI: | http://eprints.um.edu.my/id/eprint/46386 |
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