Sulaiman, Mazdida and Ebehairy, Layane and Nissapatorn, Veeranoot and Rahmatullah, Mohammed and Villegas, Jhonnel and Dupa, Helina Jean and Verzosa, Ricksterlie C. and Dolma, Karma G. and Shabaz, Muhamad and Lanting, Scholastica and Rusdi, Nor Azizun and Abdullah, Nor Hayati and Bin Break, Mohammed Khaled and Khoo, Teng Jin and Wang, Wei and Wiart, Christophe (2024) Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light. Pharmaceutical Biology, 62 (1). pp. 713-766. ISSN 1388-0209, DOI https://doi.org/10.1080/13880209.2024.2407530.
Full text not available from this repository.Abstract
ContextThe emergence of pan-resistant bacteria requires the development of new antibiotics and antibiotic potentiators.ObjectiveThis review identifies antibacterial phenolic compounds that have been identified in Asian and Pacific Angiosperms from 1945 to 2023 and analyzes their strengths and spectra of activity, distributions, molecular masses, solubilities, modes of action, structures-activities, as well as their synergistic effects with antibiotics, toxicities, and clinical potential.MethodsAll data in this review was compiled from Google Scholar, PubMed, Science Direct, Web of Science, and library search; other sources were excluded. We used the following combination of keywords: `Phenolic compound', `Plants', and `Antibacterial'. This produced 736 results. Each result was examined and articles that did not contain information relevant to the topic or coming from non-peer-reviewed journals were excluded. Each of the remaining 467 selected articles was read critically for the information that it contained.ResultsOut of similar to 350 antibacterial phenolic compounds identified, 44 were very strongly active, mainly targeting the cytoplasmic membrane of Gram-positive bacteria, and with a molecular mass between 200 and 400 g/mol. 2-Methoxy-7-methyljuglone, 6]-gingerol, anacardic acid, baicalin, vitexin, and malabaricone A and B have the potential to be developed as antibacterial leads.ConclusionsAngiosperms from Asia and the Pacific provide a rich source of natural products with the potential to be developed as leads for treating bacterial infections.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Angiosperms; Antibiotics; Asia-Pacific; Inflammation; Superbugs |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology S Agriculture > SB Plant culture |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Nov 2025 12:24 |
| Last Modified: | 03 Nov 2025 12:24 |
| URI: | http://eprints.um.edu.my/id/eprint/46325 |
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