Chong, Yoong Min and Chan, Yoke Fun and Jamaluddin, Mohamad Fadhil Hadi and Hasan, M. Shahnaz and Pang, Yong Kek and Ponnampalavanar, Sasheela and Syed Omar, Sharifah Faridah and Sam, I-Ching (2022) Rhinovirus/enterovirus was the most common respiratory virus detected in adults with severe acute respiratory infections pre-COVID-19 in Kuala Lumpur, Malaysia. PLoS ONE, 17 (9). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0273697.
Full text not available from this repository.Abstract
Background Severe acute respiratory infections (SARI) pose a great global burden. The contribution of respiratory viruses to adult SARI is relatively understudied in Asia. We aimed to determine viral aetiology of adult SARI patients in Kuala Lumpur, Malaysia. Methods The prevalence of 20 common (mainly viral) respiratory pathogens, and MERS-CoV, SARS-CoV and 5 bacterial select agents was investigated from May 2017 to October 2019 in 489 SARI adult patients in Kuala Lumpur, Malaysia, using molecular assays (Luminex NxTAG-RPP kit and qPCR assays). Viral metagenomics analysis was performed on 105 negative samples. Results Viral respiratory pathogens were detected by PCR in 279 cases (57.1%), including 10 (2.0%) additional detections by metagenomics analysis. The most detected viruses were rhinovirus/enterovirus (RV/EV) (49.1%) and influenza virus (7.4%). Three melioidosis cases were detected but no SARS-CoV, MERS-CoV or other bacterial select agents. Bacterial/ viral co-detections and viral co-detections were found in 44 (9.0%) and 27 (5.5%) cases respectively, mostly involving RV/EV. Independent predictors of critical disease were male gender, chronic lung disease, lack of runny nose and positive blood culture with a significant bacterial pathogen. Asthma and sore throat were associated with increased risk of RV/EV detection, while among RV/EV cases, males and those with neurological disease were at increased risk of critical disease. Conclusions Prior to the COVID-19 pandemic, the high prevalence of respiratory viruses in adults with SARI was mainly attributed to RV/EV. Continued surveillance of respiratory virus trends contributes to effective diagnostic, prevention, and treatment strategies.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia [FRGS/1/2020/SKK0/UM/02/5], United States Department of Defense Defense Threat Reduction Agency [HDTRA1-17-1-0027] |
| Uncontrolled Keywords: | HUMAN RHINOVIRUS; PCR ASSAY; IDENTIFICATION; AMPLIFICATION; EPIDEMIOLOGY |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine > Anaesthesiology Department Faculty of Medicine > Medical Microbiology Department Faculty of Medicine > Medicine Department |
| Depositing User: | Ms Koh Ai Peng |
| Date Deposited: | 24 Jul 2024 07:39 |
| Last Modified: | 24 Jul 2024 07:39 |
| URI: | http://eprints.um.edu.my/id/eprint/46258 |
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