Taniguchi, Manabu and Iwahashi, Misaki and Oka, Yuichiro and Tiong, Sheena Y. X. and Sato, Makoto (2022) Fezf2-positive fork cell-like neurons in the mouse insular cortex. PLoS ONE, 17 (9). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0274170.
Full text not available from this repository.Abstract
The fork cell and von Economo neuron, which are found in the insular cortex and/or the anterior cingulate cortex, are defined by their unique morphologies. Their shapes are not pyramidal; the fork cell has two primary apical dendrites and the von Economo neurons are spindle-shaped (bipolar). Presence of such neurons are reported only in the higher animals, especially in human and great ape, indicating that they are specific for most evolved species. Although it is likely that these neurons are involved in higher brain function, lack of results with experimental animals makes further investigation difficult. We here ask whether equivalent neurons exist in the mouse insular cortex. In human, Fezf2 has been reported to be highly expressed in these morphologically distinctive neurons and thus, we examined the detailed morphology of Fezf2-positive neurons in the mouse brain. Although von Economo-like neurons were not identified, Fezf2-positive fork cell-like neurons with two characteristic apical dendrites, were discovered. Examination with electron microscope indicated that these neurons did not embrace capillaries, rather they held another cell. We here term such neurons as holding neurons. We further observed several molecules, including neuromedin B (NMB) and gastrin releasing peptide (GRP) that are known to be localized in the fork cells and/or von Economo cells in human, were localized in the mouse insular cortex. Based on these observations, it is likely that an equivalent of the fork cell is present in the mouse.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [15K15015, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [17H04014], Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [2H03414] |
| Uncontrolled Keywords: | VON ECONOMO NEURONS; ANTERIOR CINGULATE; CEREBRAL-CORTEX; PROGENITORS; CONNECTIONS |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Koh Ai Peng |
| Date Deposited: | 24 Jul 2024 07:32 |
| Last Modified: | 24 Jul 2024 07:32 |
| URI: | http://eprints.um.edu.my/id/eprint/46257 |
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