Kumar, Mohit and Sharma, Ankita and Mahmood, Syed and Thakur, Anil and Mirza, Mohd Aamir and Bhatia, Amit (2024) Franz diffusion cell and its implication in skin permeation studies. Journal of Dispersion Science and Technology, 45 (5). pp. 943-956. ISSN 0193-2691, DOI https://doi.org/10.1080/01932691.2023.2188923.
Full text not available from this repository.Abstract
Franz diffusion cell was primarily used to evaluate the permeability and stability of formulations such as topical (gels and creams) and transdermal (lipid nanoparticle formulations). Diffusion cell is a straightforward assay that can reliably measure the in-vitro and ex-vivo drug release from topical preparations such as creams, ointments, liposomes formulations, and gels. It offered crucial critical perspectives on skin, drug, and formulation relationships. In addition, it is also employed for toxicity testing and quality control. Currently, many medications are available in the market, administered through transdermal routes. To treat various skin conditions, medical professionals use a wide range of methods aimed at increasing the skin's permeability and drug absorption. The biggest challenge with transdermal drug delivery system is determining the amount of medication penetrating the skin. Today, there is a lot of research into creating new dermal dosage forms for pharmaceuticals. In this review, the authors discuss various evaluation methods to determine the amount of drug penetrating the skin. With their strengths and weaknesses, these models and assessment methods provide a valuable framework for investigating the dermato-pharmacokinetics of different transdermal formulations. The assessment techniques aid in assessing molecules that cause skin irritation by shedding light on the molecular mechanisms by which they penetrate the skin. These assessment tools and models provide a novel strategy for creating topical medicinal formulations for various skin infection disorders. The present review explores Franz diffusion cell application, its implication in pharmaceutical research, and the regulation related to pharmacopeia.Graphical Abstract]
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Franz diffusion cell; In-vitro drug release; Skin deposition; Skin permeation; Transdermal drug delivery |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Centre for Natural Products Research and Drug Discovery (CENAR) Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 19 Jul 2024 02:59 |
| Last Modified: | 19 Jul 2024 02:59 |
| URI: | http://eprints.um.edu.my/id/eprint/46069 |
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