Ahire, Jayesh J. and Kumar, Vikram and Rohilla, Alka (2024) Understanding osteoporosis: Human bone density, genetic mechanisms, gut microbiota, and future prospects. Probiotics and Antimicrobial Proteins, 16 (3). pp. 875-883. ISSN 1867-1306, DOI https://doi.org/10.1007/s12602-023-10185-0.
Full text not available from this repository.Abstract
Osteoporosis is a systemic condition of the skeleton that leads to diminished bone mass, a breakdown in the bone tissue's microscopic architecture, and an elevated risk of breaking a bone. The elderly and women particularly after menopause are disproportionately affected, and the condition generally stays undiagnosed until a broken bone causes severe pain and immobility. Causes of osteoporosis include low bone mass, more than normal bone loss, changes in hormone levels (decreased estrogen or testosterone), certain diseases and therapies, and lifestyle factors like smoking and inactivity. The spine, hip, and forearm are particularly vulnerable to osteoporosis-related fractures. The purpose of this article is to present a thorough understanding of osteoporosis, including the disease's connection to bone density in humans, and the major part played by genetic pathways and gut flora. The causes of osteoporosis, the effects of aging on bone density, and why some groups experience a higher incidence of the disease than others are investigated. The paper also includes animal and human experiments investigating the link between gut flora and osteoporosis. Finally, it looks to the future and speculates on possible developments in osteoporosis prevention and therapy.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Osteoporosis; Bone density; Genetic pathways; Aging; Gut microbiota |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Jul 2024 02:33 |
| Last Modified: | 22 Jul 2024 02:33 |
| URI: | http://eprints.um.edu.my/id/eprint/45994 |
Actions (login required)
 |
View Item |
