Jaafar, Mohamad Hafis and Xu, Pei and Mageswaran, Uma-Mageswary and Balasubramaniam, Shandra-Devi and Solayappan, Maheswaran and Woon, Jia-Jie and Teh, Cindy Shuan-Ju and Todorov, Svetoslav Dimitrov and Park, Yong -Ha and Liu, Guoxia and Liong, Min-Tze (2024) Constipation anti-aging effects by dairy-based lactic acid bacteria. Journal of Animal Science and Technology, 66 (1). pp. 178-203. ISSN 2672-0191, DOI https://doi.org/10.5187/jast.2023.e93.
Full text not available from this repository.Abstract
Constipation, which refers to difficulties in defecation and infrequent bowel movement in emptying the gastrointestinal system that ultimately produces hardened fecal matters, is a health concern in livestock and aging animals. The present study aimed to evaluate the potential effects of dairy -isolated lactic acid bacteria (LAB) strains to alleviate constipation as an alternative therapeutic intervention for constipation treatment in the aging model. Rats were aged via daily subcutaneous injection of D -galactose (600 mg/body weight kg]), prior to induction of constipation via oral administration of loperamide hydrochloride (5 mg/body weight kg]). LAB strains (L. fermentum USM 4189 or L. plantarum USM 4187) were administered daily via oral gavage (1 x 10 Log CFU/day) while the control group received sterile saline. Aged rats as shown with shorter telomere lengths exhibited increased fecal bulk and soften fecal upon administration of LAB strains amid constipation as observed using the Bristol Stool Chart, accompanied by a higher fecal moisture content as compared to the control (p < 0.05). Fecal water-soluble metabolite profiles showed a reduced concentration of threonine upon administration of LAB strains compared to the control (p < 0.05). Histopathological analysis also showed that the administration of LAB strains contributed to a higher colonic goblet cell count as compared to the control (p < 0.05). The present study illustrates the potential of dairy -sourced LAB strains as probiotics to ameliorate the adverse effect of constipation amid aging, and as a potential dietary intervention strategy for dairy foods including yogurt and cheese.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Constipation; Dairy-based lactic acid bacteria (LAB); Probiotics; Aging; Dairy foods |
| Subjects: | Q Science > Q Science (General) Q Science > QR Microbiology R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medical Microbiology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Nov 2024 04:35 |
| Last Modified: | 13 Nov 2024 04:35 |
| URI: | http://eprints.um.edu.my/id/eprint/45863 |
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