Ibrahim, Intan Shazleen and Chellathurai, Melbha Starlin and Mahmood, Syed and Azmi, Amirul Hakim and Harun, Norsyifa and Nazri, Mohd Ulul Ilmie Ahmad and Mahat, Mohd Muzamir and Sofian, Zarif Mohamed (2024) Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review. International Journal of Pharmaceutics, 651. p. 123735. ISSN 0378-5173, DOI https://doi.org/10.1016/j.ijpharm.2023.123735.
Full text not available from this repository.Abstract
Colorectal cancer (CRC) continues to be one of the most prevalent and deadliest forms of cancer worldwide, despite notable advancements in its management. The prognosis for metastatic CRC remains discouraging, with a relative 5 -year survival rate for stage IV CRC patients. Conventional treatments for advanced malignancies such as chemotherapy, often face limitations in effectively targeting cancer cells resulting in off -target distribution and significant side effects. In the quest for better strategies, researchers have explored numerous alternatives. Among these, nanoparticles (NPs) specifically liposomes have emerged as one of the most promising candidates in developing targeted delivery systems for cancer therapeutics. This review discusses the current approaches employing functionalised liposomes to overcome major biological barriers in therapeutics delivery for CRC treatment. We have also shared our perspectives on the technological development of liposomes for future clinical use and highlighted a few useful insights on the material choices for future research work in CRC.
| Item Type: | Article |
|---|---|
| Funders: | Geran Penyelidikan Fakulti Farmasi Universiti Malaya (GPF001E-2020) |
| Uncontrolled Keywords: | Colorectal cancer; Modified liposomes; Targeted drug delivery system; Stimuli-responsive liposomes; PEGylated liposomes; Active ligand targeting |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Nov 2024 05:35 |
| Last Modified: | 12 Nov 2024 05:35 |
| URI: | http://eprints.um.edu.my/id/eprint/45813 |
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