Rullah, Kamal and Shamsudin, Nur Farisya and Koeberle, Andreas and Tham, Chau Ling and Fasihi Mohd Aluwi, Mohd Fadhlizil and Leong, Sze-Wei and Jantan, Ibrahim and Lam, Kok Wai (2024) Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages. Future Medicinal Chemistry, 16 (1). pp. 75-99. ISSN 1756-8919, DOI https://doi.org/10.4155/fmc-2023-0174.
Full text not available from this repository.Abstract
Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targetingMD-2, I kappa B kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression. GRAPHICS] .
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia (FRGS/1/2022/STG04/UIAM/02/2), International Islamic University of Malaysia under the Research Management Centre (RMCG20-008-0008) |
| Uncontrolled Keywords: | flavonoids; inflammatory responses; lipopolysaccharides; macrophages; monocytes |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Nov 2024 03:32 |
| Last Modified: | 12 Nov 2024 03:32 |
| URI: | http://eprints.um.edu.my/id/eprint/45796 |
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