Sahimin, Norhidayu and Low, Zhao Xuan and Hassandarvish, Pouya and Mohd Hanapi, Izzah Ruzana and Mohd Zain, Siti Nursheena and Yahaya, Hasmawati and Abu Bakar, Sazaly (2024) Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 118 (5). pp. 328-335. ISSN 0035-9203, DOI https://doi.org/10.1093/trstmh/trad097.
Full text not available from this repository.Abstract
Background: Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas.Methods: This study aimed to estimate the seroprevalence of anti-dengue and anti-chikungunya antibodies among urban refugees in the Klang Valley, Malaysia, and identify associated risk factors.Results: High seroprevalence of anti-dengue immunoglobulin G (IgG) and IgM (60.0% confidence interval {CI} 55.39 to 64.48] and 9.2% CI 6.77 to 12.25], respectively) were observed among refugees >18 years of age (chi(2)(2)=11.720, p=0.003), Kachin ethnicity (chi(2)(8)=72.253, p<0.001), without formal education (chi(2)(1)=3.856, p=0.050), homes near waste disposal sites (chi(2)(1)=10.378, p=0.001) and refugees who have experienced flooding (chi(2)(1)=5.460, p=0.019). Meanwhile, the overall seroprevalence of anti-chikungunya IgG and IgM was 9.7% (CI 7.15 to 12.73) and 10.8% (CI 8.09 to 13.93), respectively, with ages 12-18 years (chi(2)(2)=6.075, p=0.048), Rohingya ethnicity (chi(2)(8)=31.631, p<0.001) and homes close to waste disposal sites (chi(2)(1)=3.912, p=0.048) being significant risk factors. Results showed a link to poor environmental living conditions, with an increase in the vector population with higher availability of breeding sites and thus exposure to dengue and chikungunya virus.Conclusions: Health education among the community is the key to disease prevention, as there are no specific antiviral drugs for treatment and limited vaccine availability.
| Item Type: | Article |
|---|---|
| Funders: | Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR) Ministry of Higher Education, Research & Innovation, Oman, Ministry of Health, Malaysia |
| Uncontrolled Keywords: | chikungunya; dengue; Malaysia; mosquito-borne; refugees; vector-borne |
| Subjects: | Q Science > QH Natural history R Medicine > R Medicine (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Nov 2024 02:48 |
| Last Modified: | 12 Nov 2024 02:48 |
| URI: | http://eprints.um.edu.my/id/eprint/45778 |
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