Ahmadipour, Mohsen and Bhattacharya, Anish and Sarafbidabad, Mohsen and Sazali, Ezza Syuhada and Ghoshal, Sib Krishna and Satgunam, Meenaloshini and Singh, Ramesh and Ardani, Mohammad Rezaei and Missaoui, Nadhem and Kahri, Hamza and Pal, Ujjwal and Pang, Ai Ling (2024) CA19-9 and CEA biosensors in pancreatic cancer. Clinica Chimica Acta, 554. p. 117788. ISSN 0009-8981, DOI https://doi.org/10.1016/j.cca.2024.117788.
Full text not available from this repository.Abstract
Cancer is a complex pathophysiological condition causing millions of deaths each year. Early diagnosis is essential especially for pancreatic cancer. Existing diagnostic tools rely on circulating biomarkers such as Carbohydrate Antigen 19-9 (CA19-9) and Carcinoembryonic Antigen (CEA). Unfortunately, these markers are nonspecific and may be increased in a variety of disorders. Accordingly, diagnosis of pancreatic cancer generally involves more invasive approaches such as biopsy as well as imaging studies. Recent advances in biosensor technology have allowed the development of precise diagnostic tools having enhanced analytical sensitivity and specificity. Herein we examine these advances in the detection of cancer in general and in pancreatic cancer specifically. Furthermore, we highlight novel technologies in the measurement of CA19-9 and CEA and explore their future application in the early detection of pancreatic cancer.
| Item Type: | Article |
|---|---|
| Funders: | Tenaga Nasional Berhad (TNB), Universiti Tenaga Nasional (UNITEN) through the BOLD Refresh post-doctoral fellowships, DCS-Universiti Tunku Abdul Rahman, Malaysia (J510050002-IC-6 BOLDRE-FRESH2025); (IPSR/RMC/UTARRF/2023-C1/P02) |
| Uncontrolled Keywords: | Cancer biomarker; Biosensors; Clinical Diagnostics; Cancer detection; Point-of-care; Nanomaterials |
| Subjects: | T Technology > TJ Mechanical engineering and machinery |
| Divisions: | Faculty of Engineering > Department of Mechanical Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Nov 2024 06:42 |
| Last Modified: | 11 Nov 2024 06:42 |
| URI: | http://eprints.um.edu.my/id/eprint/45746 |
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