Verma, Nipun and Duseja, Ajay and Mehta, Manu and De, Arka and Lin, Huapeng and Wong, Vincent Wai-Sun and Wong, Grace Lai-Hung and Rajaram, Ruveena Bhavani and Chan, Wah-Kheong and Mahadeva, Sanjiv and Zheng, Ming-Hua and Liu, Wen-Yue and Treeprasertsuk, Sombat and Prasoppokakorn, Thaninee and Kakizaki, Satoru and Seki, Yosuke and Kasama, Kazunori and Charatcharoenwitthaya, Phunchai and Sathirawich, Phalath and Kulkarni, Anand and Purnomo, Hery Djagat and Kamani, Lubna and Lee, Yeong Yeh and Wong, Mung Seong and Tan, Eunice X. X. and Young, Dan Yock (2024) Machine learning improves the prediction of significant fibrosis in Asian patients with metabolic dysfunction-associated steatotic liver disease - The Gut and Obesity in Asia (GO-ASIA) Study. Alimentary Pharmacology & Therapeutics, 59 (6). pp. 774-788. ISSN 0269-2813, DOI https://doi.org/10.1111/apt.17891.
Full text not available from this repository.Abstract
Background: The precise estimation of cases with significant fibrosis (SF) is an unmet goal in non-alcoholic fatty liver disease (NAFLD/MASLD). Aims: We evaluated the performance of machine learning (ML) and non-patented scores for ruling out SF among NAFLD/MASLD patients. Methods: Twenty-one ML models were trained (N = 1153), tested (N = 283), and validated (N = 220) on clinical and biochemical parameters of histologically-proven NAFLD/MASLD patients (N = 1656) collected across 14 centres in 8 Asian countries. Their performance for detecting histological-SF (>= F2fibrosis) were evaluated with APRI, FIB4, NFS, BARD, and SAFE (NPV/F1-score as model-selection criteria). Results: Patients aged 47 years (median), 54.6% males, 73.7% with metabolic syndrome, and 32.9% with histological-SF were included in the study. Patients with SFvs.no-SF had higher age, aminotransferases, fasting plasma glucose, metabolic syndrome, uncontrolled diabetes, and NAFLD activity score (p < 0.001, each). ML models showed 7%-12% better discrimination than FIB-4 to detect SF. Optimised random forest (RF) yielded best NPV/F1 in overall set (0.947/0.754), test set (0.798/0.588) and validation set (0.852/0.559), as compared to FIB4 in overall set (0.744/0.499), test set (0.722/0.456), and validation set (0.806/0.507). Compared to FIB-4, RF could pick 10 times more patients with SF, reduce unnecessary referrals by 28%, and prevent missed referrals by 78%. Age, AST, ALT fasting plasma glucose, and platelet count were top features determining the SF. Sequential use of SAFE < 140 and FIB4 < 1.2 (when SAFE > 140) was next best in ruling out SF (NPV of 0.757, 0.724 and 0.827 in overall, test and validation set). Conclusions: ML with clinical, anthropometric data and simple blood investigations perform better than FIB-4 for ruling out SF in biopsy-proven Asian NAFLD/MASLD patients.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | artificial intelligence; fatty liver; liver fibrosis; mortality; NASH |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Nov 2024 08:47 |
| Last Modified: | 08 Nov 2024 08:47 |
| URI: | http://eprints.um.edu.my/id/eprint/45707 |
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