Kuek, Wee Nie and Tiang, Yi Ru and Yow, Hui Yin and Tan, Li Kar Stella and How, Chee Wun and Looi, Qi Hao Daniel and Foo, Jhi Biau (2024) Skin lightening properties of zerumbone cream: A placebo-controlled study. Journal of Cosmetic Dermatology, 23 (6). pp. 2117-2124. ISSN 1473-2130, DOI https://doi.org/10.1111/jocd.16234.
Full text not available from this repository.Abstract
Objective: Despite the demonstrated anti-melanogenic and UV protective effects of Zerumbone (ZER) in vitro, there is a lack of clinical trials that have been done to assess these properties. The primary objective of this study was to assess the effectiveness of ZER in lightening the skin tone of human participants with a single-blind approach. Methods: Twenty-six participants were randomly assigned to two groups to investigate the application location (left or right volar forearm) for the placebo and ZER creams. Both creams were topically administered to the volar forearms twice daily over a duration of 4 weeks. Initial skin irritation was assessed before and 30 min after applying creams. The melanin and erythema levels were quantified with Mexameter MX 18. Results: Twenty participants were included in the analysis. The cream formulation had excellent physical properties and was well-received by the participants. The initial skin irritation study results indicated that neither of the creams elicited an allergic reaction. The administration of ZER cream resulted in a statistically significant reduction in melanin levels (p < 0.05) after 1 week compared to the initial baseline. Furthermore, after 2 weeks of application, ZER cream demonstrated significant differences in melanin levels compared to placebo (p < 0.05). No adverse effects were observed in the group using ZER cream. Conclusion: ZER demonstrated significant potential as a skin-lightening agent.
| Item Type: | Article |
|---|---|
| Funders: | Taylor's University (FRGS/1/2019/SKK02/TAYLOR/03/2); (FRGS/1/2021/SKK0/MUSM/03/4), Taylor's University - Ministry of Higher Education (MOE) under Fundamental Research Grant Project, Monash University, as part of the Wiley - Monash University agreement via the Council of Australian University Librarians |
| Uncontrolled Keywords: | cream; formulation; skin lightening; zerumbone |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Nov 2024 03:02 |
| Last Modified: | 06 Nov 2024 03:02 |
| URI: | http://eprints.um.edu.my/id/eprint/45605 |
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