Adhesion of Candida Albicans to digital versus conventional acrylic resins: a systematic review and meta-analysis

Alhajj, Mohammed Nasser and Halboub, Esam and Yacob, Norlela and Al-Maweri, Sadeq Ali and Ahmad, Siti Fauzza and Celebic, Asja and Al-Mekhlafi, Hesham M. and Salleh, Nosizana Mohd (2024) Adhesion of Candida Albicans to digital versus conventional acrylic resins: a systematic review and meta-analysis. BMC Oral Health, 24 (1). p. 303. ISSN 1472-6831, DOI https://doi.org/10.1186/s12903-024-04083-2.

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Official URL: https://doi.org/10.1186/s12903-024-04083-2

Abstract

Background The present systematic review and meta-analysis investigated the available evidence about the adherence of Candida Albicans to the digitally-fabricated acrylic resins (both milled and 3D-printed) compared to the conventional heat-polymerized acrylic resins. Methods This study followed the guidelines of the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). A comprehensive search of online databases/search tools (Web of Science, Scopus, PubMed, Ovid, and Google Scholar) was conducted for all relevant studies published up until May 29, 2023. Only in-vitro studies comparing the adherence of Candida albicans to the digital and conventional acrylic resins were included. The quantitative analyses were performed using RevMan v5.3 software. Results Fourteen studies were included, 11 of which were meta-analyzed based on Colony Forming Unit (CFU) and Optical Density (OD) outcome measures. The pooled data revealed significantly lower candida colonization on the milled digitally-fabricated compared to the heat-polymerized conventionally-fabricated acrylic resin materials (MD = - 0.36; 95%CI = - 0.69, - 0.03; P = 0.03 and MD = - 0.04; 95%CI = - 0.06, - 0.01; P = 0.0008; as measured by CFU and OD respectively). However, no differences were found in the adhesion of Candida albicans between the 3D-printed digitally-fabricated compared to the heat-polymerized conventionally-fabricated acrylic resin materials (CFU: P = 0.11, and OD: P = 0.20). Conclusion The available evidence suggests that candida is less likely to adhere to the milled digitally-fabricated acrylic resins compared to the conventional ones.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Candida Albicans; Digital denture; CAD-CAM; Acrylic resin; Prosthodontics
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Department of Restorative Dentistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 22 Oct 2024 07:31
Last Modified: 22 Oct 2024 07:31
URI: http://eprints.um.edu.my/id/eprint/45486

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