Thy, Chun Keng and Lee, Yean Kee and Abdullah, Iskandar and Abd Rahman, Noorsaadah and Chee, Chin Fei (2024) Asymmetric Diels-Alder reaction of chalcone and isoprene mediated by titanium-based complexes. Synthetic Communications, 54 (8). pp. 636-644. ISSN 0039-7911, DOI https://doi.org/10.1080/00397911.2024.2324002.
Full text not available from this repository.Abstract
The asymmetric Diels-Alder reaction of chalcone and isoprene has been accomplished by use of chiral titanium complexes. Notably, an enantiomeric excess as high as 61% and a regioselectivity of 95% have been achieved. The preparation of the chiral titanium complexes is simple and does not require the pre-installation of a chiral auxiliary. This study represents the first example of asymmetric Diels-Alder reaction between chalcone and isoprene. GRAPHICS]
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (IIRG003B-2019); (BK044-2017), Universiti Malaya Research Grants |
| Uncontrolled Keywords: | 4+2] cycloaddition; enantiomeric synthesis; 2-methyl-1,3-butadiene; trans-chalcone; titanium tetrachloride |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry Centre for Natural Products Research and Drug Discovery (CENAR) Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Oct 2024 07:00 |
| Last Modified: | 22 Oct 2024 07:00 |
| URI: | http://eprints.um.edu.my/id/eprint/45472 |
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