Wan, Kim Sui and Moy, Foong Ming and Yusoff, Muhammad Fadhli Mohd and Mustapha, Feisul and Ismail, Mastura and Rifin, Halizah Mat and Ratnam, Kishwen Kanna Yoga and Ismail, Hasimah and Chong, Kah Kian and Ahmad, Noor Ani and Hairi, Noran Naqiah (2024) Treatment intensification and therapeutic inertia of antihypertensive therapy among patients with type 2 diabetes and hypertension with uncontrolled blood pressure. Scientific Reports, 14 (1). p. 12625. ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-024-63617-4.
Full text not available from this repository.Abstract
Treatment intensification is essential to ensure guideline targets are attained in diabetes patients. The failure to intensify treatment when the targets are not achieved is therapeutic inertia. This study aimed to determine the proportions and factors associated with treatment intensification and therapeutic inertia of antihypertensive therapy in type 2 diabetes patients with uncontrolled hypertension in Malaysia. A retrospective cohort analysis was conducted utilising registry data. Diabetes hypertensive patients with uncontrolled baseline systolic or diastolic blood pressure were included. Treatment intensification was the increase in the number of antihypertensive agents from the index treatment. Therapeutic inertia was the absence of treatment intensification when the second blood pressure reading was still uncontrolled. About 6956 patients were followed up over 2.5 +/- 1.1 person-years. Treatment intensification was observed in 29.8% of patients, while 38.6% had therapeutic inertia. Chinese, Indian, and `others' ethnic groups, retinopathy, more antihypertensive agents, and higher systolic blood pressure were associated with therapeutic inertia. Underweight, overweight patients and those with dyslipidaemia had lower risks for therapeutic inertia. The results indicate suboptimal quality of care in public health clinics in Malaysia. Further studies are needed to determine the underlying causes to formulate precise interventions to tackle the problem in Malaysia.
| Item Type: | Article |
|---|---|
| Funders: | Negeri Sembilan State Health Department |
| Uncontrolled Keywords: | Managment; Mellitus |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Sep 2024 02:01 |
| Last Modified: | 26 Sep 2024 02:01 |
| URI: | http://eprints.um.edu.my/id/eprint/45206 |
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