Farah, Nuratiqah and Lim, Chee Woei and Chin, Voon Kin and Chong, Pei Pei and Basir, Rusliza and Yeo, Wendy Wai Yeng and Tay, Sun Tee and Choo, Sulin and Lee, Tze Yan (2024) Photoactivated riboflavin inhibits planktonic and biofilm growth of Candida albicans and non-albicans Candida species. Microbial Pathogenesis, 191. p. 106665. ISSN 0882-4010, DOI https://doi.org/10.1016/j.micpath.2024.106665.
Full text not available from this repository.Abstract
Fungal infections caused by Candida species pose a serious threat to humankind. Antibiotics abuse and the ability of Candida species to form biofilm have escalated the emergence of drug resistance in clinical settings and hence, rendered it more difficult to treat Candida -related diseases. Lethal effects of Candida infection are often due to inefficacy of antimicrobial treatments and failure of host immune response to clear infections. Previous studies have shown that a combination of riboflavin with UVA (riboflavin/UVA) light demonstrate candidacidal activity albeit its mechanism of actions remain elusive. Thus, this study sought to investigate antifungal and antibiofilm properties by combining riboflavin with UVA against Candida albicans and non- albicans Candida species. The MIC 20 for the fluconazole and riboflavin/UVA against the Candida species tested was within the range of 0.125 -2 mu g/mL while the SMIC 50 was 32 mu g/mL. Present findings indicate that the inhibitory activities exerted by riboflavin/UVA towards planktonic cells are slightly less effective as compared to controls. However, the efficacy of the combination towards Candida species biofilms showed otherwise. Inhibitory effects exerted by riboflavin/UVA towards most of the tested Candida species biofilms points towards a variation in mode of action that could make it an ideal alternative therapeutic for biofilm-related infections.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant Scheme from Ministry of Higher Education (FRGS/1/2019/SKK11/PERDANA/03/1) |
| Uncontrolled Keywords: | Candida albicans; Non-albicans Candida species; Riboflavin; Fluconazole; UVA light |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Sep 2024 05:12 |
| Last Modified: | 20 Sep 2024 05:12 |
| URI: | http://eprints.um.edu.my/id/eprint/45172 |
Actions (login required)
 |
View Item |
