Rullah, Kamal and Shamsudin, Nur Farisya and Koeberle, Andreas and Tham, Chau Ling and Mohd Aluwi, Mohd Fadhlizil Fasihi and Leong, Sze Wei and Jantan, Ibrahim and Lam, Kok Wai (2024) Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages. Future Medicinal Chemistry, 16 (1). 75 – 99. ISSN 1756-8919, DOI https://doi.org/10.4155/fmc-2023-0174.
Full text not available from this repository.Abstract
Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targeting MD-2, IκB kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression. © 2024 Future Medicine Ltd.. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant no. FRGS/1/2022/STG04/UIAM/02/2], International Islamic University Malaysia [Grant no. RMCG20-008-0008] |
| Uncontrolled Keywords: | flavonoids; Inflammatory responses; Lipopolysaccharides; Macrophages; Monocytes |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Apr 2024 07:40 |
| Last Modified: | 25 Apr 2024 07:40 |
| URI: | http://eprints.um.edu.my/id/eprint/44965 |
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