Jiwanti, Prastika Krisma and Sukardi, Dewi Kartika Azizah and Sari, Anis Puspita and Tomisaki, Mai and Wafiroh, Siti and Hartati, Sri and Arramel, - and Wong, Yew Hoong and Woi, Pei Meng and Juan, Joon Ching (2024) Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin. Sensors International, 5. p. 100276. ISSN 2666-3511, DOI https://doi.org/10.1016/j.sintl.2023.100276.
Full text not available from this repository.Abstract
The uncontrolled use of ciprofloxacin (CIP) has led to increased resistance in patients and potential health issues such as kidney disorders, digestive disorder, and liver complications. This study addresses these concerns by introducing an innovative electrochemical sensor utilizing a screen-printed electrode (SPE) enhanced with a novel rGO-SnO2 nanocomposite for the precise monitoring of CIP concentration. Through square wave voltammetry (SWV), this sensor demonstrates unparalleled sensitivity and accuracy in determining CIP levels. These analyses validated the superior performance of the SPE/rGO-SnO2 electrode, revealing CIP potential range of 0.85–1.50 V with irreversible oxidation reaction and an exceptional signal-to-background (S/B) ratio of 1.91, surpassing the 1.21 ratio achieved by the SPE/rGO electrode. The SPE/rGO-SnO2 electrode also exhibited the highest active surface area (0.0252 cm2), facilitating faster transfer electron. Crucially, the SPE/rGO-SnO2 electrode exhibited an impressively low limit of detection (LOD) at 2.03 μM within a concentration range of 30–100 μM for CIP, setting a new benchmark for sensitivity (9.348 μA/μM) in CIP detection. The RSD value was less than 5 indicating that this modified electrodes exhibit good precision and stability. The real-world applicability of this developed methods was exemplified through its successful implementation in the analysis of river water and milk, achieving remarkable recovery rates of 101.2 and 97.7 , respectively. Consequently, the SPE modified with rGO-SnO2 nanocomposite emerges as a highly promising and effective tool for precise and sensitive CIP measurement, offering unparalleled performance metrics and opening avenues for enhanced environmental and health monitoring. © 2024 The Authors
| Item Type: | Article |
|---|---|
| Funders: | Kyushu University, Universitas Airlangga (1625/UN3, LPPM/PT.01.03/2023) |
| Additional Information: | Cited by: 0; All Open Access, Gold Open Access |
| Uncontrolled Keywords: | Ciprofloxacin; Electrochemical sensor; Human & health; rGO-SnO2; Screen printed electrode |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering > Department of Mechanical Engineering Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Nov 2024 08:02 |
| Last Modified: | 18 Nov 2024 08:02 |
| URI: | http://eprints.um.edu.my/id/eprint/44896 |
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