Lim, Jing-Sheng and Chai, Yoke-Yen and Ser, Wei-Xin and Van Haeren, Aniqah and Lim, Yan-Hong and Raja, Tarshiiny and Foo, Jhi-Biau and Hamzah, Sharina and Sellappans, Renukha and Yow, Hui Yin (2024) Novel drug candidates against antibiotic-resistant microorganisms: A review. Iranian Journal of Basic Medical Sciences, 27 (2). 134 – 150. ISSN 2008-3866, DOI https://doi.org/10.22038/IJBMS.2023.71672.15593.
Full text not available from this repository.Abstract
Antibiotic resistance is fast spreading globally, leading to treatment failures and adverse clinical outcomes. This review focuses on the resistance mechanisms of the top five threatening pathogens identified by the World Health Organization's global priority pathogens list: carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Pseudomonas aeruginosa, carbapenem-resistant, extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin, vancomycin-resistant Staphylococcus aureus. Several novel drug candidates have shown promising results from in vitro and in vivo studies, as well as clinical trials. The novel drugs against carbapenem-resistant bacteria include LCB10-0200, apramycin, and eravacycline, while for Enterobacteriaceae, the drug candidates are LysSAP-26, DDS-04, SPR-206, nitroxoline, cefiderocol, and plazomicin. TNP-209, KBP-7072, and CRS3123 are agents against E. faecium, while Debio 1450, gepotidacin, delafloxacin, and dalbavancin are drugs against antibiotic-resistant S. aureus. In addition to these identified drug candidates, continued in vitro and in vivo studies are required to investigate small molecules with potential antibacterial effects screened by computational receptor docking. As drug discovery progresses, preclinical and clinical studies should also be extensively conducted on the currently available therapeutic agents to unravel their potential antibacterial effect and spectrum of activity, as well as safety and efficacy profiles. © 2024 Mashhad University of Medical Sciences. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antibacterial agents Antibacterial drug resistance; Antibiotic resistance Antimicrobial agent; Drug discovery; Microbial; Pharmacology |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Jul 2024 07:50 |
| Last Modified: | 12 Jul 2024 07:50 |
| URI: | http://eprints.um.edu.my/id/eprint/44866 |
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