Saniasiaya, Jeyasakthy and van der Meer, Graeme and Toll, Ed C and McCaffer, Craig and Barber, Colin and Neeff, Michel (2024) Familial congenital laryngotracheal stenosis: A systematic review. International Journal of Pediatric Otorhinolaryngology, 177. ISSN 0165-5876, DOI https://doi.org/10.1016/j.ijporl.2023.111841.
Full text not available from this repository.Abstract
Background: Congenital laryngotracheal stenosis (CLS) is a rare cause of stridor among newborns. Evidence has shown that several family members can be affected by CLS. Knowledge of the pathophysiology of familial congenital laryngotracheal stenosis (FCLS) will enable more effective therapeutic strategies. Objective: To determine the clinical course and outcome of familial congenital laryngotracheal stenosis (FCLS). Methods: A literature search was conducted over a period of one month (September 2023) by searching several databases to identify studies published from inception to 31st August 2023. Results: Of 256 papers identified, five articles met the inclusion criteria. A total of 17 patients with slight female predominance (59 ) were identified. Familial congenital tracheal stenosis was reported in female twins (100 ). A variety of clinical presentations were listed. An endoscopic airway study was performed on all patients. 64.8 of the included children were managed surgically. Genetic studies performed on 41 of children could not locate genetic abnormalities. Conclusion: Consanguinity, twin births, and female gender could be predisposing factors for FCLS, although the quality of evidence is low due to the rarity of the condition. © 2023 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Congenital upper airway obstruction; Familial; Genetic predisposition; Laryngotracheal stenosis; Outcome |
| Subjects: | R Medicine > RF Otorhinolaryngology |
| Divisions: | Faculty of Medicine > Otorhinolaryngology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Jun 2024 08:16 |
| Last Modified: | 26 Jun 2024 08:16 |
| URI: | http://eprints.um.edu.my/id/eprint/44836 |
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