Ngadni, Muhammad Afiq and Chong, Soon-Lim and Kamarudin, Muhamad Noor Alfarizal and Hazni, Hazrina and Litaudon, Marc and Supratman, Unang and Awang, Khalijah (2024) Erythrocarpines I–N, new limonoids from the barks of Chisocheton erythrocarpus and their neuroprotective effects against hydrogen peroxide in NG108–15 cells. Fitoterapia, 173. p. 105765. ISSN 0367-326X, DOI https://doi.org/10.1016/j.fitote.2023.105765.
Full text not available from this repository.Abstract
A phytochemical study on the bark of Chisocheton erythrocarpus Hiern (Meliaceae) has led to the isolation of six new phragmalin-type limonoids named erythrocarpines I – N (1–6) along with one known limonoid, erythrocarpine F (7). Their structures were fully characterized by spectroscopic methods. The pre-treatment of NG108–15 cells with 1–5, 7 (2 h) demonstrated low to good protective effects against H2O2 exposure; 1 (83.77 ± 1.84 at 12.5 μM), 2 (69.07 ± 2.01 at 12.5 μM), 3 (80.38 ± 2.1 at 12.5 μM), 4 (62.33 ± 1.95 at 25 μM),5 (58.67 ± 1.85 at 50 μM) and 7 (66.07 ± 2.03 at 12.5 μM). Interestingly, 1 and 3 demonstrated comparable protective effects to positive control epigallocatechin gallate (EGCG) with similar cell viability capacity (≈ 80), having achieved that at lower concentration (12.5 μM) than EGCG (50 μM). Collectively, the results suggested the promising use of 1 and 3 as potential neuroprotective agents against hydrogen peroxide-induced cytotoxicity in neuronal model. © 2023 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | Malaysia's Ministry of Higher Education (PR002-2019A) |
| Additional Information: | Cited by: 0 |
| Uncontrolled Keywords: | epigallocatechin gallate; hydrogen peroxide; limonoid; 108CC15 cell line; article; bark; cell viability; controlled study; cytotoxicity; drug analysis; drug development; human; neuroprotection; pharmacology |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Department of Chemistry Centre for Natural Products Research and Drug Discovery (CENAR) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Nov 2024 07:59 |
| Last Modified: | 15 Nov 2024 07:59 |
| URI: | http://eprints.um.edu.my/id/eprint/44768 |
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