Chellathurai, Melbha Starlin and Mahmood, Syed and Sofian, Zarif Mohamed and Hee, Cheng Wan and Sundarapandian, Ramkanth and Ahamed, Haja Nazeer and Kandasamy, C. S. and Hilles, Ayah R. and Hashim, Najihah Mohd and Janakiraman, Ashok Kumar (2024) Biodegradable polymeric insulin microneedles - A design and materials perspective review. Drug Delivery, 31 (1). ISSN 1521-0464, DOI https://doi.org/10.1080/10717544.2023.2296350.
Full text not available from this repository.Abstract
Microneedle (MN) delivery devices are more accepted by people than regular traditional needle injections (e.g. vaccination) due to their simplicity and adaptability. Thus, patients of chronic diseases like diabetes look for alternative pain-free treatment regimens circumventing regular subcutaneous injections. Insulin microneedles (INS-MNs) are a thoughtfully researched topic (1) to overcome needle phobia in patients, (2) for controlled delivery of the peptide, (3) decreasing the frequency of drug administration, (4) to ease the drug administration procedure, and (5) thus increasing patient adherence to the treatment dosage regimes. MNs physically disrupt the hard outer skin layer to create minuscule pores for insulin (INS) to pass through the dermal capillaries into the systemic circulation. Biodegradable polymeric MNs are of greater significance for INS and vaccine delivery than silicon, metal, glass, or non-biodegradable polymeric MNs due to their ease of fabrication, mass production, cost-effectiveness, and bioerodability. In recent years, INS-MNs have been researched to deliver INS through the transdermal implants, buccal mucosa, stomach wall, intestinal mucosal layers, and colonic mucosa apart from the usual transdermal delivery. This review focuses on the design characteristics and the applications of biodegradable/dissolvable polymeric INS-MNs in transdermal, intra-oral, gastrointestinal (GI), and implantable delivery. The prospective approaches to formulate safe, controlled-release INS-MNs were highlighted. Biodegradable/dissolvable polymers, their significance, their impact on MN morphology, and INS release characteristics were outlined. The developments in biodegradable polymeric INS-MN technology were briefly discussed. Bio-erodible polymer selection, MN fabrication and evaluation factors, and other design aspects were elaborated.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia, UCSI University |
| Uncontrolled Keywords: | Diabetes; Transdermal insulin delivery; Oral insulin microneedles; Biopolymeric insulin microneedles; Implantable insulin microneedles; Non-parenteral insulin delivery |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Centre for Natural Products Research and Drug Discovery (CENAR) Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Jul 2024 01:02 |
| Last Modified: | 16 Jul 2024 07:20 |
| URI: | http://eprints.um.edu.my/id/eprint/44151 |
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