Rahmadi, Mahardian and Ardianto, Chrismawan and Nurhan, Ahmad D. and Chasanah, Rafiqa A. and Krismonika, Dewi I. and Puspitasari, Arina D. and Suprapti, Budi and Segaran, Santhra and Phan, Chia Wei and Khotib, Junaidi (2022) Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression. Research Results in Pharmacology, 8 (4). 65 – 75. ISSN 2658-381X, DOI https://doi.org/10.3897/rrpharmacology.8.82242.
Full text not available from this repository.Abstract
Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl is a common laxative used to treat constipation. To date, the effects of bisacodyl on AQP3 and AQP4 expression and the role this interaction plays in constipation are unclear. This study aimed to determine the effects of bisacodyl on AQP3 and AQP4 expression in mice after induction of constipation with morphine. Materials and methods: The laxative effects of bisacodyl on both acute and chronic morphine-induced constipation were determined. Fecal water content, colonic bead expulsion, and colonic mRNA levels for AQP3 and AQP4 mRNA were measured. Results and discussion: The administration of morphine to mice resulted in decreased fecal water content, longer bead expulsion times, and increased AQP3 and AQP4 mRNA levels in the colon. Meanwhile, bisacodyl administration prevented the morphine-induced changes in fecal water content, bead expulsion time, and AQP3 and AQP4 mRNA levels in the colons of mice. Conclusion: This study suggests that bisacodyl may prevent morphine-induced constipation by preventing morphine- induced increases in AQP3 and AQP4 expression in the colon. Copyright 2022 Bontsevich RA et al.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | AQP3; AQP4; Health risk; Laxative; Opioid-induced constipation |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Dec 2023 02:03 |
| Last Modified: | 01 Dec 2023 02:03 |
| URI: | http://eprints.um.edu.my/id/eprint/44063 |
Actions (login required)
 |
View Item |
