Zaidi, Noorzaileen Eileena and Shazali, Nur Aima Hafiza and Leow, Thean Chor and Osman, Mohd Azuraidi and Ibrahim, Kamariah and Rahman, Nik Mohd Afizan Nik Abd (2022) Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression. BioMedicine (Taiwan), 12 (4). 9 – 19. ISSN 2211-8020, DOI https://doi.org/10.37796/2211-8039.1381.
Full text not available from this repository.Abstract
Over the last few decades, cancer has been regarded as an independent and self sustaining progression. The earliest hallmarks of cancer comprise of sustaining proliferative signalling, avoiding growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Nonetheless, two emerging hallmarks are being described: aberrant metabolic pathways and evasion of immune destruction. Changes in tumour cell metabolism are not restricted to tumour cells alone; the products of the altered metabolism have a direct impact on the activity of immune cells inside the tumour microenvironment, particularly tumour-associated macrophages (TAMs). The complicated process of cancer growth is orchestrated by metabolic changes dictating the tight mutual connection between these cells. Here, we discuss approaches to exploit the interaction of cancer cells' abnormal metabolic activity and TAMs. We also describe ways to exploit it by reprogramming fatty acid metabolism via TAMs. © the Author(s).
| Item Type: | Article |
|---|---|
| Funders: | Universiti Putra Malaysia |
| Uncontrolled Keywords: | Fatty acid metabolism; Invasion; Metastasis; Oleic acid; Palmitic acid; Tumour-associated macrophages |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Dec 2023 08:02 |
| Last Modified: | 01 Dec 2023 08:02 |
| URI: | http://eprints.um.edu.my/id/eprint/43969 |
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