Lim, Chee Chean and Lu, Jia Lei and Kulasegarah, Jeyanthi (2022) Osimertinib-induced hearing loss: an uncommon aftereffect of a novel drug—a case report. Egyptian Journal of Otolaryngology, 38 (1). p. 64. ISSN 1012-5574, DOI https://doi.org/10.1186/s43163-022-00250-w.
Full text not available from this repository.Abstract
Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have significantly improved survival outcomes of advanced non-small cell lung cancer (NSCLC). Nonetheless, usage of TKIs is not without adverse effects, as it has been reported to cause irreversible sensorineural hearing loss (SNHL). Case presentation: We describe a 72-year-old man who experienced hearing loss after taking osimertinib for 6 months. Later, his hearing further declined over a period of 1 year. Hearing rehabilitation with high-powered behind-the-ear (BTE) hearing aid has helped to improve his quality of life to some degree. There were no other known causative factors leading to the hearing deterioration. To date, there is no case report on osimertinib-induced SNHL. Conclusion: Physicians ought to counsel patients on osimertinib of this rare side effect and monitor for early signs of hearing loss. Treatment protocol should be in place taking into account that they have either failed or likely to fail the first- or second-line treatments and have advanced stage disease. © 2022, The Author(s).
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Cited by: 0; All Open Access, Gold Open Access |
| Uncontrolled Keywords: | osimertinib; aged; Article; auditory rehabilitation; brain metastasis; cancer size; cancer staging; case report; chronic cough; clinical article; clinical protocol; computer assisted tomography; CT guided biopsy; drug monitoring; drug safety; headache; hoarseness; human; lung adenocarcinoma; lung biopsy; male; nuclear magnetic resonance imaging; otoscopy; patient counseling; perception deafness; positron emission tomography; pure tone audiometry; quality of life; treatment duration; treatment planning |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RF Otorhinolaryngology |
| Divisions: | Faculty of Medicine > Otorhinolaryngology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Nov 2024 09:00 |
| Last Modified: | 18 Nov 2024 09:00 |
| URI: | http://eprints.um.edu.my/id/eprint/43745 |
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