AL-Bayaty, Fouad H. and Razak, Muhammad Azly Abdul and Hussain, Saba F. and Mulok, Tengku Z. and Almas, Khalid and Smith, Steph and Abdulla, Mahmood A. (2022) Antibacterial activity of salvadora persica and benzylisothiocyanate against prevotella intermedia and eikenella corrodens incorporated into periodontal chips. Journal of International Dental and Medical Research, 15 (2). 498 -504. ISSN 1309-100X,
Full text not available from this repository.Abstract
Salvadora persica (S. persica) contains steam-distillable oil made of 90 Benzylisothiocyanate (BITC). It’s proven to have a wide range of bactericidal activity. The objectives of this study were to develop biodegradable periodontal chips containing S. persica, and BITC in a chitosan base and to evaluate their antibacterial activity against Prevotella intermedia and Eikenella corrodens. Periodontal chips were developed that incorporated S. persica (Miswak) extract and BITC in a chitosan base. Sterile distilled water was used as negative control while chlohexidine was used as positive control. A gel diffusion test was performed to detect the potential antibacterial activity followed by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) Tests. Scanning electron microscopy (SEM) was used to identify the morphology and configuration of Prevotella intermedia and Eikenella corrodens bacteria before and after treatment with chips. The mean inhibition zone for the S. persica chips was found to be 9.0 mm. The MIC and MBC tests demostrated that all the concentrations for the chips succesfully inhibited the growth of the bacteria. Chlohexidine used as positive control also inhibited the bacteria. The negative control of sterile distilled water showed no inhibtion of bacterial growth. SEM showed that all chips produced distinct alterations to the bacterial morphology. E. corrodens and P. intermedia underwent shrinkage and formed irregular shapes. Periodontal chips formulated from S. persica and BITC incorporated into a chitosan base as a target drug delivery method, showed potent antibacterial activity against E. corrodens and P. intermedia. © 2022. Journal of International Dental and Medical Research. All Rights Reserved.
| Item Type: | Article |
|---|---|
| Funders: | University Technology MARA [Grant No: 198/2009, 600-RMI/ST/DANA5/3/ Dst], Hallym University Medical Center |
| Uncontrolled Keywords: | Anti-bacterial activity; Benzyl isothiocyanate chips; Chitosan; Salvadora persica chips |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Oct 2023 03:01 |
| Last Modified: | 30 Oct 2023 03:01 |
| URI: | http://eprints.um.edu.my/id/eprint/43571 |
Actions (login required)
 |
View Item |
