Loo, Hou Chan and Osman, Fairuz and Ho, Siew Lee and An, Sing Yee and Yong, Yim Meiau and Khoo, Ee Ming (2022) Incidence of angiotensin-converting enzyme inhibitor-induced cough in a Malaysian public primary care clinic: a retrospective cohort study. Malaysian Family Physician, 17 (1). 66 -70. ISSN 1985-207X, DOI https://doi.org/10.51866/oa.80.
Full text not available from this repository.Abstract
Introduction: The incidence of angiotensin-converting enzyme inhibitors (ACEi)-induced cough has been reported between 5 and 30 but is unknown in Malaysia. This study aimed to determine the incidence of ACEi-induced cough and its associated factors in a public primary care clinic in Malaysia. Methods: A retrospective review of electronic medical records of patients who were initiated ACEi between January 1, 2015, and December 31, 2015, and reviewed until July 31, 2016. A total of 1,091 patients were newly prescribed ACEi, and 394 patients were eligible for this study. We excluded patients who defaulted follow-ups with no further clinic visits before July 31, 2016, were transferred to the clinic without the recorded date of ACEi initiation, were transferred to other clinics during the study period, were followed up at other clinics and attended the study clinic for a short period, or were given only a stat dose of ACEi. Results: Among the 394 patients initiated on ACEi, 225 (57.1) were male, 369 (93.7) were Malay, 376 (95.4) had hypertension, and 192 (48.7) had diabetes. The incidence of ACEiinduced cough was 24.1, and 42 (10.7) patients developed cough on the day of therapy initiation. There was no association between age, gender, ethnicity, type of ACEi, and cough. Conclusion: Approximately one quarter of patients developed cough after ACEi initiation, and approximately half of them developed cough within 1 week of ACEi initiation. Doctors should consider early follow-up for patients initiated on ACEi therapy to ensure adherence, quality of life, and minimise unnecessary treatment. © 2022, Academy of Family Physicians of Malaysia. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Angiotensin-converting enzyme inhibitor; Cough; Incidence |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Primary Care Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 02 Nov 2023 04:51 |
| Last Modified: | 02 Nov 2023 04:51 |
| URI: | http://eprints.um.edu.my/id/eprint/43545 |
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