Beshir, Semira Abdi and Aadithsoorya, A.M. and Parveen, Affana and Goh, Sheron Sir Loon and Hussain, Nadia and Menon, Vineetha Bharathan (2022) Aducanumab therapy to treat Alzheimer's disease: A narrative review. International Journal of Alzheimer's Disease, 2022. ISSN 20908024, DOI https://doi.org/10.1155/2022/9343514.
Full text not available from this repository.Abstract
Background. Aducanumab, a new monoclonal antibody that targets β-amyloid aggregates, has been granted conditional approval by the U.S. FDA for treatment of mild Alzheimer's disease (AD). The approval of this drug without a confirmed significant clinical impact has resulted in several debates. Objective. In this narrative review, aducanumab approval-related controversy, the drug's pharmacokinetics and pharmacodynamic characteristics, evidence from the efficacy and safety trials of aducanumab, implications of the drug approval, and the future directions in the management of patients with AD are summarized. Methods. Using relevant keywords, Google Scholar, Web of Science, and MEDLINE databases and manufacturer's website were searched. Results. Infusion of aducanumab at a higher dose resulted in a modest slowing of cognitive decline among patients with mild cognitive impairment or early-onset AD dementia. The drug however can cause amyloid-related imaging abnormalities. Due to modest impact on cognition, the use of this drug by patients with AD will most likely be limited. The manufacturer is required to run an extended phase IIIb trial to verify the benefit of this drug. Access to therapy requires a careful selection of patients and periodic monitoring to ensure the optimal use of the drug. Conclusion. Despite the limitations, aducanumab is the first disease-modifying therapy approved for the treatment of AD. Aducanumab addresses a part of the pathogenesis of AD; therefore, drugs that can act on multiple targets are needed. In addition, the search for preventive strategies, validated plasma-based assays, and newer drugs for AD, which are effective, safe, convenient, and affordable, is vital. © 2022 Semira Abdi Beshir et al.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Cited by: 23; All Open Access, Gold Open Access, Green Open Access |
| Uncontrolled Keywords: | Aducanumab; Alzheimer disease; Drug approval; Drug efficacy; Drug safety; Human; Medline; Mild cognitive impairment; pharmacodynamics; pharmacokinetic parameters; Review; search engine; Web of Science |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Nov 2024 04:06 |
| Last Modified: | 09 Nov 2024 04:06 |
| URI: | http://eprints.um.edu.my/id/eprint/43312 |
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