Chong, Jia Cherng and Hashim, Hanizasurana and Mohamed Iqbal, Tajunisah Begam (2022) Effect of intravitreal anti-VEGF injection on choroidal thickness in patients with diabetic macula edema; 玻璃体腔内注射抗VEGF对糖尿病性黄斑水肿患者脉络膜厚度的影响. International Eye Science, 22 (1). 1 -8. ISSN 1672-5123, DOI https://doi.org/10.3980/j.issn.1672-5123.2022.1.01.
Full text not available from this repository.Abstract
AIM: To investigate for any detectable change in sub-foveal choroidal thickness following intravitreal injections of Ranibizumab or Aflibercept in patients with central involving diabetic macula edema (DME), evidenced by optical coherence tomography (OCT). METHODS: Totally 17 patients with central involving DME who required and agreed to intravitreal anti-VEGF injection were invited to be the subject of this study. These injection-naive subjects were undergone three loading doses of monthly intravitreal anti-VEGF (Ranibizumab 0.5 mg/0.05 mL for 9 patients or Aflibercept 2 mg/0.05 mL for 8 patients) injection, and a clinic review appointment 1mo after the third injection. The changes of foveal choroidal thickness, visual acuity and central retinal thickness at 1mo were observed before and after treatment in 2 groups by enhanced depth image-optical coherence tomography (EDI-OCT). RESULTS: We recorded a significant sub-foveal choroidal thinning and vision improvement after three loading doses of anti-VEGF (all P<0.05). The thinning effect between Ranibizumab and Aflibercept group was insignificant (all P>0.05). There was no significant correlation between pre-treatment sub-foveal choroidal thickness and vision improvement (rs=-0.269, P=0.296). There was also no significant correlation between choroidal thickness changes with vision improvement, central retinal thickness change and age of subjects (all P >0.05). CONCLUSION: Intravitreal Ranibizumab and Aflibercept injections both leads to significant sub-foveal choroidal thinning in DME subjects. It was accompanied with significant vision improvement with no evidence of immediate detrimental effect of choroidal thinning. Future research with a longer study duration would help in establishing the duration and long term effect of choroidal thinning. Copyright 2022 by the IJO Press.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Aflibercept; Ranibizumab; Vasculotropin; Adult; Article; Central retinal thickness; Choroidal thickness; Clinical article; Controlled study; Cross-sectional study; Diabetic macular edema; Drug efficacy; Drug safety; Female; Human; Intraocular pressure; Male; Observational study; Optical coherence tomography; Prospective study; Randomized controlled trial; Retina fovea; Subfoveal choroidal thickness; Thermoregulation; Visual acuity |
| Subjects: | R Medicine > RE Ophthalmology |
| Divisions: | Faculty of Medicine > Department of Ophthalmology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Oct 2023 06:10 |
| Last Modified: | 09 Oct 2023 06:10 |
| URI: | http://eprints.um.edu.my/id/eprint/43161 |
Actions (login required)
 |
View Item |
