Cao, Wanxiu and Chen, Xin and Chin, Yaoxian and Zheng, Jinkai and Lim, Phaik Eem and Xue, Changhu and Tang, Qingjuan (2022) Identification of curcumin as a potential alpha-glucosidase and dipeptidyl-peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation. Journal Of Food Biochemistry, 46 (3, SI). ISSN 0145-8884, DOI https://doi.org/10.1111/jfbc.13686.
Full text not available from this repository.Abstract
Natural compounds have tremendous potential to regulate glucose metabolism, but conventional methods for studying their bioactivities are usually labor intensive. Here, hypoglycemic properties in 22 selected food-derived compounds were examined using molecular docking. The results indicated that curcumin is an inhibitor of both alpha-glucosidase and dipeptidyl-peptidase 4 (DPP-4), which are important for glycemic control. These effects of curcumin were also confirmed by enzymatic determination in vitro. Furthermore, curcumin significantly improved diet-induced hyperglycemia (e.g., fasting plasma glucose levels and glycogen storage in muscle or liver) in mice. This might be attributed to its inhibitory effects on the activities of alpha-glucosidase and DPP-4 in vivo. Curcumin also upregulated the expression of genes (e.g., glucagon-like peptide 1) related to DPP-4 activity in the small intestine. In conclusion, curcumin is a potential ingredient of functional foods used for diet-induced hyperglycemia management. Practical applications Curcumin has been widely used as a colorant in the food industry. Moreover, a growing number of studies have described its diverse biological functions, such as anti-inflammatory, anti-oxidant, and anti-angiogenic activities. Thus, curcumin is regarded as a potential ingredient in functional foods. Our results highlighted the hyperglycemic effect of curcumin, suggesting that curcumin may be included in food products for hyperglycemic patients.
| Item Type: | Article |
|---|---|
| Funders: | Key R&D project of Shandong Province (Grant No. 2019GHY112058) |
| Uncontrolled Keywords: | curcumin; dipeptidyl‐ peptidase 4; hyperglycemia; molecular docking; α ‐ glucosidase |
| Subjects: | Q Science > QD Chemistry Q Science > QK Botany |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Oct 2023 13:47 |
| Last Modified: | 08 Oct 2023 13:47 |
| URI: | http://eprints.um.edu.my/id/eprint/42460 |
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