Lau, Meng-Fei and Chua, Kek Heng and Sabaratnam, Vikineswary and Kuppusamy, Umah Rani (2022) In vitro anti-colorectal cancer potential of the medicinal mushroom Ganoderma neo-japonicum Imazeki in hyperglycemic condition: Impact on oxidative stress, cell cycle and apoptosis. Nutrition and Cancer-An International Journal, 74 (3). pp. 978-995. ISSN 0163-5581, DOI https://doi.org/10.1080/01635581.2021.1931701.
Full text not available from this repository.Abstract
Clinical efficacy of chemotherapy is often compromised by diabetogenic glucose on colorectal cancer (CRC). High glucose has been shown to diminish the cytotoxicity of anticancer drugs. The issue can potentially be addressed with natural products. Recently, we revealed that Ganoderma neo-japonicum exhibits inhibitory activities against human colonic carcinoma cells. In this study, the impacts of hexane fraction (Hex, sterol-enriched) and chloroform fraction (Chl, terpenoid-enriched) were further elucidated. The cellular responses, including oxidative stress, cell cycle, and apoptosis were compared between the presence of normal glucose (NG, 5.5 mM) and high glucose (HG, 25 mM). HG promoted cell viability with concomitant elevation of GSH level. Both Hex and Chl fractions stimulated NO production, in addition, induced cell cycle arrest. The apoptotic effect of Hex fraction was glucose-dependent, but Chl fraction triggered apoptosis with an equivalent extent in NG and HG conditions. Overall, the active fractions from G. neo-japonicum show therapeutic potential in managing hyperglycemia-associated CRC.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Anti-colorectal cancer; Medicinal mushroom; Ganoderma neo-japonicum Imazeki; Hyperglycemic condition |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Biomedical Science Department Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Oct 2023 06:33 |
| Last Modified: | 09 Oct 2023 06:34 |
| URI: | http://eprints.um.edu.my/id/eprint/42454 |
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