Cummins, Emer and Waseem, Rida and Piyasena, Deween and Wang, Chew Yin and Suen, Colin and Ryan, Clodagh and Wong, Jean and Kryger, Meir and Chung, Frances (2022) Can the complete blood count be used as a reliable screening tool for obstructive sleep apnea? Sleep and Breathing, 26 (2). pp. 613-620. DOI https://doi.org/10.1007/s11325-021-02383-3.
Full text not available from this repository.Abstract
Purpose Since hypoxia increases erythropoietin production and inflammation, the complete blood count (CBC) has been proposed as an inexpensive alternative for obstructive sleep apnea (OSA) screening. The objective of this study was to determine whether or not intermittent hypoxia and OSA severity, as measured by the mean oxygen saturation (SpO(2)) and apnea-hypopnea index (AHI), affect parameters measured by the CBC. Methods This retrospective study included a total of 941 surgical patients who had a pre-operative home sleep study. The pre-operative CBC was extracted from the electronic patient records. Patients were stratified according to their AHI scores, into mild (AHI >= 5 - < 15), moderate (AHI >= 15 - < 30), and severe (AHI >= 30) OSA groups. Results There were 244 patients without OSA, 294 with mild, 223 with moderate, and 180 with severe OSA. Our analysis showed that hemoglobin (P = 0.010), hematocrit (P = 0.027), and basophils (P = 0.006) showed significant changes among the different severities of OSA. For mean SpO(2), there were negative associations with body mass index (r = - 0.287; P < 0.001), age (r = - 0.077; P = 0.021), hemoglobin (r = - 0.208; P < 0.001), hematocrit (r = - 0.220; P < 0.001), red blood cells (r = - 0.107; P = 0.001), mean corpuscular volume (MCV) (r = - 0.159; P < 0.001), mean corpuscular hemoglobin (r = - 0.142; P < 0.001), and basophils (r = - 0.091; P = 0.007). All analyzed parameters remained within normal clinical range. Multivariable regression identified hemoglobin, MCV, and basophils to be independent predictors of mean SpO(2) and AHI. Conclusion Hemoglobin, MCV, and basophils were independently associated with intermittent hypoxia defined by mean SpO(2) and AHI. Adding CBC parameters to other screening tools for OSA may have additional value due to its association with changes in mean SpO(2.)
| Item Type: | Article |
|---|---|
| Funders: | University Health Network Foundation, Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto |
| Uncontrolled Keywords: | Obstructive sleep apnea; Hematological parameters; Complete blood count; Hemoglobin; Apnea-hypopnea index; Hypoxia |
| Subjects: | R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Medicine > Anaesthesiology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Oct 2023 04:03 |
| Last Modified: | 07 Oct 2023 04:03 |
| URI: | http://eprints.um.edu.my/id/eprint/42447 |
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